CCCTC-Binding Factor

"CCCTC-Binding Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.

Descriptor ID	D000076246
MeSH Number(s)	D12.776.157.687.157 D12.776.260.120 D12.776.660.235.050 D12.776.660.720.157 D12.776.664.235.050 D12.776.930.780.563
Concept/Terms	CCCTC-Binding Factor CCCTC-Binding Factor CCCTC Binding Factor DNA-Binding Protein CTCF CTCF, DNA-Binding Protein DNA Binding Protein CTCF CTCF Protein

Below are MeSH descriptors whose meaning is more general than "CCCTC-Binding Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Poly-ADP-Ribose Binding Proteins [D12.776.157.687]
CCCTC-Binding Factor [D12.776.157.687.157]
DNA-Binding Proteins [D12.776.260]
CCCTC-Binding Factor [D12.776.260.120]
Nuclear Proteins [D12.776.660]
Chromosomal Proteins, Non-Histone [D12.776.660.235]
CCCTC-Binding Factor [D12.776.660.235.050]
Poly-ADP-Ribose Binding Proteins [D12.776.660.720]
CCCTC-Binding Factor [D12.776.660.720.157]
Nucleoproteins [D12.776.664]
Chromosomal Proteins, Non-Histone [D12.776.664.235]
CCCTC-Binding Factor [D12.776.664.235.050]
Transcription Factors [D12.776.930]
Repressor Proteins [D12.776.930.780]
CCCTC-Binding Factor [D12.776.930.780.563]

Below are MeSH descriptors whose meaning is related to "CCCTC-Binding Factor".

Below are MeSH descriptors whose meaning is more specific than "CCCTC-Binding Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CCCTC-Binding Factor" by people in this website by year, and whether "CCCTC-Binding Factor" was a major or minor topic of these publications.

Bar chart showing 9 publications over 6 distinct years, with a maximum of 3 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	0	1	1
2011	0	1	1
2012	0	2	2
2014	0	1	1
2017	0	3	3
2021	1	0	1

Below are the most recent publications written about "CCCTC-Binding Factor" by people in Profiles.

Sivapragasam S, Stark B, Albrecht AV, Bohm KA, Mao P, Emehiser RG, Roberts SA, Hrdlicka PJ, Poon GMK, Wyrick JJ. CTCF binding modulates UV damage formation to promote mutation hot spots in melanoma. EMBO J. 2021 10 18; 40(20):e107795.

View in: PubMed
Isoda T, Moore AJ, He Z, Chandra V, Aida M, Denholtz M, Piet van Hamburg J, Fisch KM, Chang AN, Fahl SP, Wiest DL, Murre C. Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate. Cell. 2017 Sep 21; 171(1):103-119.e18.

View in: PubMed
Hashimoto H, Wang D, Horton JR, Zhang X, Corces VG, Cheng X. Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. Mol Cell. 2017 Jun 01; 66(5):711-720.e3.

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Huang Y, Koues OI, Zhao JY, Liu R, Pyfrom SC, Payton JE, Oltz EM. cis-Regulatory Circuits Regulating NEK6 Kinase Overexpression in Transformed B Cells Are Super-Enhancer Independent. Cell Rep. 2017 03 21; 18(12):2918-2931.

View in: PubMed
Ideraabdullah FY, Thorvaldsen JL, Myers JA, Bartolomei MS. Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region. Hum Mol Genet. 2014 Dec 01; 23(23):6246-59.

View in: PubMed
Macaluso M, Caracciolo V, Rizzo V, Sun A, Montanari M, Russo G, Bellipanni G, Khalili K, Giordano A. Integrating role of T antigen, Rb2/p130, CTCF and BORIS in mediating non-canonical endoplasmic reticulum-dependent death pathways triggered by chronic ER stress in mouse medulloblastoma. Cell Cycle. 2012 May 01; 11(9):1841-50.

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Fiorentino FP, Giordano A. The tumor suppressor role of CTCF. J Cell Physiol. 2012 Feb; 227(2):479-92.

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Fiorentino FP, Macaluso M, Miranda F, Montanari M, Russo A, Bagella L, Giordano A. CTCF and BORIS regulate Rb2/p130 gene transcription: a novel mechanism and a new paradigm for understanding the biology of lung cancer. Mol Cancer Res. 2011 Feb; 9(2):225-33.

View in: PubMed
Chau CM, Zhang XY, McMahon SB, Lieberman PM. Regulation of Epstein-Barr virus latency type by the chromatin boundary factor CTCF. J Virol. 2006 Jun; 80(12):5723-32.

View in: PubMed

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