Mutagenesis, Insertional

"Mutagenesis, Insertional" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.

Descriptor ID	D016254
MeSH Number(s)	E05.393.420.601.550 G05.365.590.575 G05.558.550
Concept/Terms	Mutagenesis, Insertional Mutagenesis, Insertional Insertional Mutagenesis Sequence Insertion Sequence Insertion Insertion, Sequence Insertions, Sequence Sequence Insertions Viral Insertional Mutagenesis Viral Insertional Mutagenesis Insertional Mutagenesis, Viral Mutagenesis, Viral Insertional Linker-Insertion Mutagenesis Linker-Insertion Mutagenesis Linker Insertion Mutagenesis Mutagenesis, Linker-Insertion Gene Insertion Gene Insertion Gene Insertions Insertion, Gene Insertions, Gene Insertion Mutation Insertion Mutation Insertion Mutations Mutation, Insertion Mutations, Insertion Insertional Activation Insertional Activation Activation, Insertional Activations, Insertional Insertional Activations Mutagenesis, Cassette Mutagenesis, Cassette Cassette Mutagenesis

Below are MeSH descriptors whose meaning is more general than "Mutagenesis, Insertional".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Genetic Engineering [E05.393.420]
Protein Engineering [E05.393.420.601]
Mutagenesis, Insertional [E05.393.420.601.550]
Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Variation [G05.365]
Mutation [G05.365.590]
Mutagenesis, Insertional [G05.365.590.575]
Mutagenesis [G05.558]
Mutagenesis, Insertional [G05.558.550]

Below are MeSH descriptors whose meaning is related to "Mutagenesis, Insertional".

Below are MeSH descriptors whose meaning is more specific than "Mutagenesis, Insertional".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mutagenesis, Insertional" by people in this website by year, and whether "Mutagenesis, Insertional" was a major or minor topic of these publications.

Bar chart showing 33 publications over 18 distinct years, with a maximum of 3 publications in 1996 and 2009 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	2	3
1997	0	2	2
1998	0	2	2
2000	0	2	2
2002	1	1	2
2003	0	1	1
2004	0	2	2
2005	0	2	2
2006	1	1	2
2008	1	0	1
2009	2	1	3
2010	1	2	3
2011	0	2	2
2012	1	0	1
2013	0	2	2
2014	0	1	1
2017	1	0	1
2019	0	1	1

Below are the most recent publications written about "Mutagenesis, Insertional" by people in Profiles.

Tarnauskaite ?, Bicknell LS, Marsh JA, Murray JE, Parry DA, Logan CV, Bober MB, de Silva DC, Duker AL, Sillence D, Wise C, Jackson AP, Murina O, Reijns MAM. Biallelic variants in DNA2 cause microcephalic primordial dwarfism. Hum Mutat. 2019 08; 40(8):1063-1070.

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Mesarich CH, Rees-George J, Gardner PP, Ghomi FA, Gerth ML, Andersen MT, Rikkerink EH, Fineran PC, Templeton MD. Transposon insertion libraries for the characterization of mutants from the kiwifruit pathogen Pseudomonas syringae pv. actinidiae. PLoS One. 2017; 12(3):e0172790.

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Schaefer-Ramadan S, Thorpe C, Rozovsky S. Site-specific insertion of selenium into the redox-active disulfide of the flavoprotein augmenter of liver regeneration. Arch Biochem Biophys. 2014 Apr 15; 548:60-5.

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Ueberham L, Bollmann A, Shoemaker MB, Arya A, Adams V, Hindricks G, Husser D. Genetic ACE I/D polymorphism and recurrence of atrial fibrillation after catheter ablation. Circ Arrhythm Electrophysiol. 2013 Aug; 6(4):732-7.

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Treff NR, Fedick A, Tao X, Devkota B, Taylor D, Scott RT. Evaluation of targeted next-generation sequencing-based preimplantation genetic diagnosis of?monogenic disease. Fertil Steril. 2013 Apr; 99(5):1377-1384.e6.

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Al-Hinai MA, Fast AG, Papoutsakis ET. Novel system for efficient isolation of Clostridium double-crossover allelic exchange mutants enabling markerless chromosomal gene deletions and DNA integration. Appl Environ Microbiol. 2012 Nov; 78(22):8112-21.

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Liu C, Sanders JM, Pascal JM, Hou YM. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases. RNA. 2012 Feb; 18(2):213-21.

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Lai-Cheong JE, Moss C, Parsons M, Almaani N, McGrath JA. Revertant mosaicism in Kindler syndrome. J Invest Dermatol. 2012 Mar; 132(3 Pt 1):730-2.

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Li H, Malani N, Hamilton SR, Schlachterman A, Bussadori G, Edmonson SE, Shah R, Arruda VR, Mingozzi F, Wright JF, Bushman FD, High KA. Assessing the potential for AAV vector genotoxicity in a murine model. Blood. 2011 Mar 24; 117(12):3311-9.

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de Silva S, Mastrangelo MA, Lotta LT, Burris CA, Izsv?k Z, Ivics Z, Bowers WJ. Herpes simplex virus/Sleeping Beauty vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo. Hum Gene Ther. 2010 Nov; 21(11):1603-13.

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