Receptors, Aryl Hydrocarbon

"Receptors, Aryl Hydrocarbon" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.

Descriptor ID	D018336
MeSH Number(s)	D12.776.260.643.715 D12.776.826.209.715 D12.776.930.760
Concept/Terms	Receptors, Aryl Hydrocarbon Receptors, Aryl Hydrocarbon Aryl Hydrocarbon Receptor Receptor, Aryl Hydrocarbon Aryl Hydrocarbon Receptors Dioxin Receptor Receptor, Dioxin Dioxin Receptors Receptors, Dioxin Polyaromatic Hydrocarbon Receptors Polyaromatic Hydrocarbon Receptor Receptor, Polyaromatic Hydrocarbon Receptors, Polyaromatic Hydrocarbon TCDD Receptor Receptor, TCDD Receptors, TCDD TCDD Receptors AH Receptor Receptor, AH AH Receptors Receptors, AH Receptors, 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Below are MeSH descriptors whose meaning is more general than "Receptors, Aryl Hydrocarbon".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Orphan Nuclear Receptors [D12.776.260.643]
Receptors, Aryl Hydrocarbon [D12.776.260.643.715]
Receptors, Cytoplasmic and Nuclear [D12.776.826]
Orphan Nuclear Receptors [D12.776.826.209]
Receptors, Aryl Hydrocarbon [D12.776.826.209.715]
Transcription Factors [D12.776.930]
Receptors, Aryl Hydrocarbon [D12.776.930.760]

Below are MeSH descriptors whose meaning is related to "Receptors, Aryl Hydrocarbon".

Below are MeSH descriptors whose meaning is more specific than "Receptors, Aryl Hydrocarbon".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, Aryl Hydrocarbon" by people in this website by year, and whether "Receptors, Aryl Hydrocarbon" was a major or minor topic of these publications.

Bar chart showing 9 publications over 6 distinct years, with a maximum of 3 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Total
2005	3	3
2011	1	1
2013	1	1
2014	2	2
2018	1	1
2021	1	1

Below are the most recent publications written about "Receptors, Aryl Hydrocarbon" by people in Profiles.

Trikha P, Moseman JE, Thakkar A, Campbell AR, Elmas E, Foltz JA, Chakravarti N, Fitch JR, Mardis ER, Lee DA. Defining the AHR-regulated transcriptome in NK cells reveals gene expression programs relevant to development and function. Blood Adv. 2021 11 23; 5(22):4605-4618.

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Scoville SD, Nalin AP, Chen L, Chen L, Zhang MH, McConnell K, Beceiro Casas S, Ernst G, Traboulsi AA, Hashi N, Williams M, Zhang X, Hughes T, Mishra A, Benson DM, Saultz JN, Yu J, Freud AG, Caligiuri MA, Mundy-Bosse BL. Human AML activates the aryl hydrocarbon receptor pathway to impair NK cell development and function. Blood. 2018 10 25; 132(17):1792-1804.

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Hughes T, Briercheck EL, Freud AG, Trotta R, McClory S, Scoville SD, Keller K, Deng Y, Cole J, Harrison N, Mao C, Zhang J, Benson DM, Yu J, Caligiuri MA. The transcription Factor AHR prevents the differentiation of a stage 3 innate lymphoid cell subset to natural killer cells. Cell Rep. 2014 Jul 10; 8(1):150-62.

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Borland MG, Krishnan P, Lee C, Albrecht PP, Shan W, Bility MT, Marcus CB, Lin JM, Amin S, Gonzalez FJ, Perdew GH, Peters JM. Modulation of aryl hydrocarbon receptor (AHR)-dependent signaling by peroxisome proliferator-activated receptor ?/d (PPAR?/d) in keratinocytes. Carcinogenesis. 2014 Jul; 35(7):1602-12.

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Lahoti TS, Hughes JM, Kusnadi A, John K, Zhu B, Murray IA, Gowda K, Peters JM, Amin SG, Perdew GH. Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Pharmacol Exp Ther. 2014 Feb; 348(2):236-45.

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Lindsey S, Papoutsakis ET. The aryl hydrocarbon receptor (AHR) transcription factor regulates megakaryocytic polyploidization. Br J Haematol. 2011 Feb; 152(4):469-84.

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Murray IA, Reen RK, Leathery N, Ramadoss P, Bonati L, Gonzalez FJ, Peters JM, Perdew GH. Evidence that ligand binding is a key determinant of Ah receptor-mediated transcriptional activity. Arch Biochem Biophys. 2005 Oct 01; 442(1):59-71.

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Wassenberg DM, Nerlinger AL, Battle LP, Di Giulio RT. Effects of the polycyclic aromatic hydrocarbon heterocycles, carbazole and dibenzothiophene, on in vivo and in vitro CYP1A activity and polycyclic aromatic hydrocarbon-derived embryonic deformities. Environ Toxicol Chem. 2005 Oct; 24(10):2526-32.

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Patel RD, Kim DJ, Peters JM, Perdew GH. The aryl hydrocarbon receptor directly regulates expression of the potent mitogen epiregulin. Toxicol Sci. 2006 Jan; 89(1):75-82.

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