Proto-Oncogene Proteins c-kit

"Proto-Oncogene Proteins c-kit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.

Descriptor ID	D019009
MeSH Number(s)	D08.811.913.696.620.682.725.400.050 D12.776.543.750.630.124 D12.776.543.750.705.852.150.100 D12.776.543.750.750.400.200.170 D12.776.624.664.700.183
Concept/Terms	Proto-Oncogene Proteins c-kit Proto-Oncogene Proteins c-kit Proto Oncogene Proteins c kit c-kit, Proto-Oncogene Proteins Stem Cell Factor Receptor SCF Receptor p145 c-kit c-kit, p145 p145 c kit p145(c-kit) p145c-kit p145c kit CD117 Antigen Antigens, CD117 CD117 Antigens Proto-Oncogene Protein c-kit Proto Oncogene Protein c kit c-kit, Proto-Oncogene Protein c-kit Protein c kit Protein kit Proto-Oncogene Protein Proto-Oncogene Protein, kit kit Proto Oncogene Protein Receptor, Stem Cell Factor Proto-Oncogene Protein kit Proto Oncogene Protein kit c-kit Receptor c kit Receptor

Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-kit".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
Proto-Oncogene Proteins c-kit [D08.811.913.696.620.682.725.400.050]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
Proto-Oncogene Proteins c-kit [D12.776.543.750.630.124]
Receptors, Immunologic [D12.776.543.750.705]
Receptors, Cytokine [D12.776.543.750.705.852]
Receptors, Colony-Stimulating Factor [D12.776.543.750.705.852.150]
Proto-Oncogene Proteins c-kit [D12.776.543.750.705.852.150.100]
Receptors, Peptide [D12.776.543.750.750]
Receptors, Growth Factor [D12.776.543.750.750.400]
Receptors, Colony-Stimulating Factor [D12.776.543.750.750.400.200]
Proto-Oncogene Proteins c-kit [D12.776.543.750.750.400.200.170]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
Proto-Oncogene Proteins c-kit [D12.776.624.664.700.183]

Below are MeSH descriptors whose meaning is related to "Proto-Oncogene Proteins c-kit".

Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-kit".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proto-Oncogene Proteins c-kit" by people in this website by year, and whether "Proto-Oncogene Proteins c-kit" was a major or minor topic of these publications.

Bar chart showing 68 publications over 18 distinct years, with a maximum of 8 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
2001	1	0	1
2002	3	4	7
2003	3	4	7
2004	1	1	2
2005	4	2	6
2006	4	4	8
2007	5	2	7
2008	2	4	6
2009	0	5	5
2010	0	1	1
2011	1	4	5
2012	0	2	2
2013	2	0	2
2015	1	0	1
2016	0	1	1
2017	0	2	2
2019	0	4	4

Below are the most recent publications written about "Proto-Oncogene Proteins c-kit" by people in Profiles.

Glod J, Arnaldez FI, Wiener L, Spencer M, Killian JK, Meltzer P, Dombi E, Derse-Anthony C, Derdak J, Srinivasan R, Linehan WM, Miettinen M, Steinberg SM, Helman L, Widemann BC. A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor. Clin Cancer Res. 2019 11 01; 25(21):6302-6308.

View in: PubMed
Kobayashi M, Inaguma S, Raffeld M, Kato H, Suzuki S, Wakasugi T, Mitsui A, Kuwabara Y, Lasota J, Ikeda H, Miettinen M, Takahashi S. Epithelioid variant of gastrointestinal stromal tumor harboring PDGFRA mutation and MLH1 gene alteration: A case report. Pathol Int. 2019 Sep; 69(9):541-546.

View in: PubMed
Lasota J, Kowalik A, Felisiak-Golabek A, Zieba S, Waloszczyk P, Masiuk M, Wejman J, Szumilo J, Miettinen M. Primary malignant melanoma of esophagus: clinicopathologic characterization of 20 cases including molecular genetic profiling of 15 tumors. Mod Pathol. 2019 07; 32(7):957-966.

View in: PubMed
Lasota J, Kowalik A, Felisiak-Golabek A, Zieba S, Wang ZF, Miettinen M. New Mechanisms of mTOR Pathway Activation in KIT-mutant Malignant GISTs. Appl Immunohistochem Mol Morphol. 2019 01; 27(1):54-58.

View in: PubMed
Yang H, Kurtenbach S, Guo Y, Lohse I, Durante MA, Li J, Li Z, Al-Ali H, Li L, Chen Z, Field MG, Zhang P, Chen S, Yamamoto S, Li Z, Zhou Y, Nimer SD, Harbour JW, Wahlestedt C, Xu M, Yang FC. Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies. Blood. 2018 Jan 18; 131(3):328-341.

View in: PubMed
Miettinen M, Felisiak-Golabek A, Wang Z, Inaguma S, Lasota J. GIST Manifesting as a Retroperitoneal Tumor: Clinicopathologic Immunohistochemical, and Molecular Genetic Study of 112 Cases. Am J Surg Pathol. 2017 May; 41(5):577-585.

View in: PubMed
Boikos SA, Pappo AS, Killian JK, LaQuaglia MP, Weldon CB, George S, Trent JC, von Mehren M, Wright JA, Schiffman JD, Raygada M, Pacak K, Meltzer PS, Miettinen MM, Stratakis C, Janeway KA, Helman LJ. Molecular Subtypes of KIT/PDGFRA Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Gastrointestinal Stromal Tumor Clinic. JAMA Oncol. 2016 Jul 01; 2(7):922-8.

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Caywood EH, Kolb EA. Challenges in Converting Acute Myeloid Leukemia (AML) Genomics Into AML Clinical Trials. J Clin Oncol. 2015 Dec 20; 33(36):4238-9.

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Lombaert IM, Abrams SR, Li L, Eswarakumar VP, Sethi AJ, Witt RL, Hoffman MP. Combined KIT and FGFR2b signaling regulates epithelial progenitor expansion during organogenesis. Stem Cell Reports. 2013; 1(6):604-19.

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Miettinen M, Lasota J. Gastrointestinal stromal tumors. Gastroenterol Clin North Am. 2013 Jun; 42(2):399-415.

View in: PubMed

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