"Cathepsin A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A carboxypeptidase that catalyzes the release of a C-terminal amino acid with a broad specificity. It also plays a role in the LYSOSOMES by protecting BETA-GALACTOSIDASE and NEURAMINIDASE from degradation. It was formerly classified as EC 3.4.12.1 and EC 3.4.21.13.
| Descriptor ID |
D043402
|
| MeSH Number(s) |
D08.811.277.656.224.062 D08.811.277.656.350.245.260 D08.811.277.656.959.200
|
| Concept/Terms |
Cathepsin A- Cathepsin A
- beta-Galactosidase Protective Protein
- beta Galactosidase Protective Protein
- BGPP
- Serine Carboxypeptidase I
- Carboxypeptidase Y
- Endothelin Degradation Enzyme
- Lysosomal Protective Protein
- Acid Carboxypeptidase
- Carboxypeptidase C
|
Below are MeSH descriptors whose meaning is more general than "Cathepsin A".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin A".
This graph shows the total number of publications written about "Cathepsin A" by people in this website by year, and whether "Cathepsin A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cathepsin A" by people in Profiles.
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Bonten EJ, Campos Y, Zaitsev V, Nourse A, Waddell B, Lewis W, Taylor G, d'Azzo A. Heterodimerization of the sialidase NEU1 with the chaperone protective protein/cathepsin A prevents its premature oligomerization. J Biol Chem. 2009 Oct 09; 284(41):28430-28441.
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Leimig T, Mann L, Martin Mdel P, Bonten E, Persons D, Knowles J, Allay JA, Cunningham J, Nienhuis AW, Smeyne R, d'Azzo A. Functional amelioration of murine galactosialidosis by genetically modified bone marrow hematopoietic progenitor cells. Blood. 2002 May 1; 99(9):3169-78.
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Rottier RJ, Hahn CN, Mann LW, del Pilar Martin M, Smeyne RJ, Suzuki K, d'Azzo A. Lack of PPCA expression only partially coincides with lysosomal storage in galactosialidosis mice: indirect evidence for spatial requirement of the catalytic rather than the protective function of PPCA. Hum Mol Genet. 1998 Oct; 7(11):1787-94.