GTP-Binding Protein alpha Subunits, G12-G13
"GTP-Binding Protein alpha Subunits, G12-G13" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed family of heterotrimeric GTP-binding protein alpha subunits that signal through interactions with a variety of second messengers as GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; and HEAT SHOCK PROTEINS. The G12-G13 part of the name is also spelled G12/G13.
| Descriptor ID |
D044365
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| MeSH Number(s) |
D08.811.277.040.330.300.200.100.100 D12.644.360.360.100.100 D12.776.157.325.332.100.100 D12.776.476.375.100.100 D12.776.543.325.100.100
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| Concept/Terms |
GTP-Binding Protein alpha Subunits, G12-G13- GTP-Binding Protein alpha Subunits, G12-G13
- GTP Binding Protein alpha Subunits, G12 G13
- G-Protein, G12-G13 alpha Subunits
- G Protein, G12 G13 alpha Subunits
- G-Protein, G12-G13 alpha Family
- G Protein, G12 G13 alpha Family
GTP-Binding Protein alpha Subunit, G13- GTP-Binding Protein alpha Subunit, G13
- GTP Binding Protein alpha Subunit, G13
- G13 G-Protein
- G-Protein, G13
- G13 G Protein
- G(13) Protein
- Galpha13 Protein
- G-Protein, G13 Subunit
- G Protein, G13 Subunit
- G13 Subunit G-Protein
- Subunit G-Protein, G13
- G13 Protein
- G alpha13 Protein
- alpha13 Protein, G
GTP-Binding Protein alpha Subunit, G12- GTP-Binding Protein alpha Subunit, G12
- GTP Binding Protein alpha Subunit, G12
- G12 alpha Protein
- alpha Protein, G12
- G12 Protein
- Protein, G12
- G-Protein, G12 Subunit
- G Protein, G12 Subunit
- G12 Subunit G-Protein
- Subunit G-Protein, G12
- G alpha12 Protein
- alpha12 Protein, G
- Galpha12 Protein
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Below are MeSH descriptors whose meaning is more general than "GTP-Binding Protein alpha Subunits, G12-G13".
Below are MeSH descriptors whose meaning is more specific than "GTP-Binding Protein alpha Subunits, G12-G13".
This graph shows the total number of publications written about "GTP-Binding Protein alpha Subunits, G12-G13" by people in this website by year, and whether "GTP-Binding Protein alpha Subunits, G12-G13" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2005 | 2 | 1 | 3 |
| 2009 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "GTP-Binding Protein alpha Subunits, G12-G13" by people in Profiles.
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McDuffie EL, Panettieri RA, Scott CP. G12/13 signaling in asthma. Respir Res. 2024 Aug 02; 25(1):295.
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Douglas AE, Heim JA, Shen F, Almada LL, Riobo NA, Fernández-Zapico ME, Manning DR. The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened. J Biol Chem. 2011 Sep 2; 286(35):30714-22.
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Chahdi A, Sorokin A. The role of beta(1)Pix/caveolin-1 interaction in endothelin signaling through Galpha subunits. Biochem Biophys Res Commun. 2010 Jan 15; 391(3):1330-5.
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Bhattacharyya R, Banerjee J, Khalili K, Wedegaertner PB. Differences in Galpha12- and Galpha13-mediated plasma membrane recruitment of p115-RhoGEF. Cell Signal. 2009 Jun; 21(6):996-1006.
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McLaughlin JN, Shen L, Holinstat M, Brooks JD, Dibenedetto E, Hamm HE. Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1. J Biol Chem. 2005 Jul 1; 280(26):25048-59.
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Grabocka E, Wedegaertner PB. Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF. Oncogene. 2005 Mar 24; 24(13):2155-65.
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Riobo NA, Manning DR. Receptors coupled to heterotrimeric G proteins of the G12 family. Trends Pharmacol Sci. 2005 Mar; 26(3):146-54.
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Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB. Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement. J Biol Chem. 2003 Aug 1; 278(31):28793-8.
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Bhattacharyya R, Wedegaertner PB. Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF. Biochem J. 2003 May 1; 371(Pt 3):709-20.
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Bhattacharyya R, Wedegaertner PB. Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. J Biol Chem. 2000 May 19; 275(20):14992-9.