NFATC Transcription Factors
"NFATC Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.
| Descriptor ID |
D050778
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| MeSH Number(s) |
D12.776.930.608
|
| Concept/Terms |
NFATC Transcription Factors- NFATC Transcription Factors
- Transcription Factors, NFATC
- Transcription Factor NF-AT
- NF-AT, Transcription Factor
- Transcription Factor NF AT
- Nuclear Factor of Activated T-Cells, Cytoplasmic
- Nuclear Factor of Activated T Cells, Cytoplasmic
- NFAT Proteins
- NFATC Proteins
- Nuclear Factors of Activated T-Cells
- Nuclear Factors of Activated T Cells
- NF-AT Proteins
- NF AT Proteins
NFAT Transcription Factor 4- NFAT Transcription Factor 4
- NFATC3 Transcription Factor
- Factor, NFATC3 Transcription
- Transcription Factor, NFATC3
- NFATx Protein
- Nuclear Factor of Activated T-Cells, Cytoplasmic 3 Protein
- Nuclear Factor of Activated T Cells, Cytoplasmic 3 Protein
- NF-AT4 Protein
- NF AT4 Protein
- NFAT4 Protein
- NFATC3 Protein
NFAT Transcription Factor 2- NFAT Transcription Factor 2
- NFAT-2 Protein
- NFAT 2 Protein
- Nuclear Factor of Activated T-Cells, Cytoplasmic 1 Protein
- Nuclear Factor of Activated T Cells, Cytoplasmic 1 Protein
- NFATC1 Protein
- NFATC1 Transcription Factor
- Factor, NFATC1 Transcription
- Transcription Factor, NFATC1
- NF-ATc1 Protein
- NF ATc1 Protein
- NFAT2 Protein
NFAT Transcription Factor 3- NFAT Transcription Factor 3
- NFATC4 Transcription Factor
- Transcription Factor, NFATC4
- NFAT3 Protein
- NFATC4 Protein
- Nuclear Factor of Activated T-Cells, Cytoplasmic 4 Protein
- Nuclear Factor of Activated T Cells, Cytoplasmic 4 Protein
- NF-AT3 Protein
- NF AT3 Protein
NFAT Transcription Factor 5- NFAT Transcription Factor 5
- Nuclear Factor of Activated T-Cells 5 Protein
- Nuclear Factor of Activated T Cells 5 Protein
- OREBP Protein
- Osmotic Response Element Binding Protein
- NFATL1 Protein
- Tonicity-Responsive Enhancer-Binding Protein
- Tonicity Responsive Enhancer Binding Protein
- NFAT5 Protein
- NFATz Protein
- TonEBP Protein
NFAT Transcription Factor 1- NFAT Transcription Factor 1
- NFATC2 Transcription Factor
- Factor, NFATC2 Transcription
- Transcription Factor, NFATC2
- NFAT1 Protein
- NFATC2 Protein
- Nuclear Factor of Activated T-Cells, Cytoplasmic 2 Protein
- Nuclear Factor of Activated T Cells, Cytoplasmic 2 Protein
- NFAT-1 Protein
- NFAT 1 Protein
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Below are MeSH descriptors whose meaning is more general than "NFATC Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "NFATC Transcription Factors".
This graph shows the total number of publications written about "NFATC Transcription Factors" by people in this website by year, and whether "NFATC Transcription Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "NFATC Transcription Factors" by people in Profiles.
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Kinoshita SM, Krutzik PO, Nolan GP. COP9 signalosome component JAB1/CSN5 is necessary for T cell signaling through LFA-1 and HIV-1 replication. PLoS One. 2012; 7(7):e41725.
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Hiyama A, Gogate SS, Gajghate S, Mochida J, Shapiro IM, Risbud MV. BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs. J Bone Miner Res. 2010 May; 25(5):1179-90.
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Hiyama A, Gajghate S, Sakai D, Mochida J, Shapiro IM, Risbud MV. Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc. J Biol Chem. 2009 Apr 10; 284(15):9824-34.
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Aizu T, Tamai K, Nakano H, Rokunohe D, Toyomaki Y, Uitto J, Sawamura D. Calcineurin/NFAT-dependent regulation of 230-kDa bullous pemphigoid antigen (BPAG1) gene expression in normal human epidermal keratinocytes. J Dermatol Sci. 2008 Jul; 51(1):45-51.
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Tone Y, Furuuchi K, Kojima Y, Tykocinski ML, Greene MI, Tone M. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat Immunol. 2008 Feb; 9(2):194-202.
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Tsai TT, Danielson KG, Guttapalli A, Oguz E, Albert TJ, Shapiro IM, Risbud MV. TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc. J Biol Chem. 2006 Sep 1; 281(35):25416-24.
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Ammit AJ, Lazaar AL, Irani C, O'Neill GM, Gordon ND, Amrani Y, Penn RB, Panettieri RA. Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists. Am J Respir Cell Mol Biol. 2002 Apr; 26(4):465-74.