NFATC Transcription Factors

"NFATC Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.

Descriptor ID	D050778
MeSH Number(s)	D12.776.930.608
Concept/Terms	NFATC Transcription Factors NFATC Transcription Factors Transcription Factors, NFATC Transcription Factor NF-AT NF-AT, Transcription Factor Transcription Factor NF AT Nuclear Factor of Activated T-Cells, Cytoplasmic Nuclear Factor of Activated T Cells, Cytoplasmic NFAT Proteins NFATC Proteins Nuclear Factors of Activated T-Cells Nuclear Factors of Activated T Cells NF-AT Proteins NF AT Proteins NFAT Transcription Factor 4 NFAT Transcription Factor 4 NFATC3 Transcription Factor Factor, NFATC3 Transcription Transcription Factor, NFATC3 NFATx Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 3 Protein Nuclear Factor of Activated T Cells, Cytoplasmic 3 Protein NF-AT4 Protein NF AT4 Protein NFAT4 Protein NFATC3 Protein NFAT Transcription Factor 2 NFAT Transcription Factor 2 NFAT-2 Protein NFAT 2 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 1 Protein Nuclear Factor of Activated T Cells, Cytoplasmic 1 Protein NFATC1 Protein NFATC1 Transcription Factor Factor, NFATC1 Transcription Transcription Factor, NFATC1 NF-ATc1 Protein NF ATc1 Protein NFAT2 Protein NFAT Transcription Factor 3 NFAT Transcription Factor 3 NFATC4 Transcription Factor Transcription Factor, NFATC4 NFAT3 Protein NFATC4 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 4 Protein Nuclear Factor of Activated T Cells, Cytoplasmic 4 Protein NF-AT3 Protein NF AT3 Protein NFAT Transcription Factor 5 NFAT Transcription Factor 5 Nuclear Factor of Activated T-Cells 5 Protein Nuclear Factor of Activated T Cells 5 Protein OREBP Protein Osmotic Response Element Binding Protein NFATL1 Protein Tonicity-Responsive Enhancer-Binding Protein Tonicity Responsive Enhancer Binding Protein NFAT5 Protein NFATz Protein TonEBP Protein NFAT Transcription Factor 1 NFAT Transcription Factor 1 NFATC2 Transcription Factor Factor, NFATC2 Transcription Transcription Factor, NFATC2 NFAT1 Protein NFATC2 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 2 Protein Nuclear Factor of Activated T Cells, Cytoplasmic 2 Protein NFAT-1 Protein NFAT 1 Protein

Below are MeSH descriptors whose meaning is more general than "NFATC Transcription Factors".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
NFATC Transcription Factors [D12.776.930.608]

Below are MeSH descriptors whose meaning is related to "NFATC Transcription Factors".

Below are MeSH descriptors whose meaning is more specific than "NFATC Transcription Factors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NFATC Transcription Factors" by people in this website by year, and whether "NFATC Transcription Factors" was a major or minor topic of these publications.

Bar chart showing 18 publications over 12 distinct years, with a maximum of 3 publications in 2006 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2004	0	1	1
2006	1	2	3
2007	2	0	2
2008	1	0	1
2009	1	0	1
2010	1	0	1
2011	1	0	1
2012	0	2	2
2014	2	1	3
2015	1	0	1
2016	1	0	1

Below are the most recent publications written about "NFATC Transcription Factors" by people in Profiles.

Shoshan E, Braeuer RR, Kamiya T, Mobley AK, Huang L, Vasquez ME, Velazquez-Torres G, Chakravarti N, Ivan C, Prieto V, Villares GJ, Bar-Eli M. NFAT1 Directly Regulates IL8 and MMP3 to Promote Melanoma Tumor Growth and Metastasis. Cancer Res. 2016 06 01; 76(11):3145-55.

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Tomkowicz B, Walsh E, Cotty A, Verona R, Sabins N, Kaplan F, Santulli-Marotto S, Chin CN, Mooney J, Lingham RB, Naso M, McCabe T. TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway. PLoS One. 2015; 10(10):e0140694.

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Hullmann JE, Grisanti LA, Makarewich CA, Gao E, Gold JI, Chuprun JK, Tilley DG, Houser SR, Koch WJ. GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity. Circ Res. 2014 Dec 05; 115(12):976-85.

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Lodhi N, Kossenkov AV, Tulin AV. Bookmarking promoters in mitotic chromatin: poly(ADP-ribose)polymerase-1 as an epigenetic mark. Nucleic Acids Res. 2014 Jun; 42(11):7028-38.

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Steinebrunner N, Sandig C, Sommerer C, Hinz U, Giese T, Stremmel W, Zahn A. Pharmacodynamic monitoring of nuclear factor of activated T cell-regulated gene expression in liver allograft recipients on immunosuppressive therapy with calcineurin inhibitors in the course of time and correlation with acute rejection episodes--a prospective study. Ann Transplant. 2014 Jan 22; 19:32-40.

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Kinoshita SM, Krutzik PO, Nolan GP. COP9 signalosome component JAB1/CSN5 is necessary for T cell signaling through LFA-1 and HIV-1 replication. PLoS One. 2012; 7(7):e41725.

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del Blanco B, Garc?a-Mariscal A, Wiest DL, Hern?ndez-Munain C. Tcra enhancer activation by inducible transcription factors downstream of pre-TCR signaling. J Immunol. 2012 Apr 01; 188(7):3278-93.

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Zahn A, Schott N, Hinz U, Stremmel W, Schmidt J, Ganten T, Gotthardt D, Meuer S, Zeier M, Giese T, Sommerer C. Immunomonitoring of nuclear factor of activated T cells-regulated gene expression: the first clinical trial in liver allograft recipients. Liver Transpl. 2011 Apr; 17(4):466-73.

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Hiyama A, Gogate SS, Gajghate S, Mochida J, Shapiro IM, Risbud MV. BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs. J Bone Miner Res. 2010 May; 25(5):1179-90.

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Hiyama A, Gajghate S, Sakai D, Mochida J, Shapiro IM, Risbud MV. Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc. J Biol Chem. 2009 Apr 10; 284(15):9824-34.

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