Interferon-Stimulated Gene Factor 3
"Interferon-Stimulated Gene Factor 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multimeric complex that functions as a ligand-dependent transcription factor. ISGF3 is assembled in the CYTOPLASM and translocated to the CELL NUCLEUS in response to INTERFERON signaling. It consists of ISGF3-GAMMA and ISGF3-ALPHA, and it regulates expression of many interferon-responsive GENES.
| Descriptor ID |
D050832
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| MeSH Number(s) |
D12.644.360.024.303 D12.776.157.057.061 D12.776.260.513 D12.776.476.024.386 D12.776.930.354
|
| Concept/Terms |
Interferon-Stimulated Gene Factor 3- Interferon-Stimulated Gene Factor 3
- Interferon Stimulated Gene Factor 3
- Transcription Factor ISGF3
- ISGF3, Transcription Factor
- ISGF3 Transcription Factor
- Transcription Factor, ISGF3
- IFN-Stimulated Gene Factor 3 Complex
- IFN Stimulated Gene Factor 3 Complex
- ISGF3 Factor
|
Below are MeSH descriptors whose meaning is more general than "Interferon-Stimulated Gene Factor 3".
Below are MeSH descriptors whose meaning is more specific than "Interferon-Stimulated Gene Factor 3".
This graph shows the total number of publications written about "Interferon-Stimulated Gene Factor 3" by people in this website by year, and whether "Interferon-Stimulated Gene Factor 3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
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Below are the most recent publications written about "Interferon-Stimulated Gene Factor 3" by people in Profiles.
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Wu WZ, Sun HC, Gao YQ, Li Y, Wang L, Zhou K, Liu KD, Iliakis G, Tang ZY. Reduction in p48-ISGFgamma levels confers resistance to interferon-alpha2a in MHCC97 cells. Oncology. 2004; 67(5-6):428-40.
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Miettinen M, Lehtonen A, Julkunen I, Matikainen S. Lactobacilli and Streptococci activate NF-kappa B and STAT signaling pathways in human macrophages. J Immunol. 2000 Apr 01; 164(7):3733-40.
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Pearse RN, Feinman R, Shuai K, Darnell JE, Ravetch JV. Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3. Proc Natl Acad Sci U S A. 1993 May 01; 90(9):4314-8.