Receptors, Notch

"Receptors, Notch" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the CELL NUCLEUS, where they act as transcription factors.

Descriptor ID	D051880
MeSH Number(s)	D12.776.543.750.725 D12.776.930.770
Concept/Terms	Receptors, Notch Receptors, Notch Notch Proteins Notch Receptors

Below are MeSH descriptors whose meaning is more general than "Receptors, Notch".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Notch [D12.776.543.750.725]
Transcription Factors [D12.776.930]
Receptors, Notch [D12.776.930.770]

Below are MeSH descriptors whose meaning is related to "Receptors, Notch".

Below are MeSH descriptors whose meaning is more specific than "Receptors, Notch".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, Notch" by people in this website by year, and whether "Receptors, Notch" was a major or minor topic of these publications.

Bar chart showing 23 publications over 11 distinct years, with a maximum of 6 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	2	2
2003	0	1	1
2004	0	1	1
2008	2	0	2
2009	2	0	2
2010	1	0	1
2011	3	1	4
2012	6	0	6
2014	0	2	2
2016	0	1	1
2022	1	0	1

Below are the most recent publications written about "Receptors, Notch" by people in Profiles.

Zhou B, Lin W, Long Y, Yang Y, Zhang H, Wu K, Chu Q. Notch signaling pathway: architecture, disease, and therapeutics. Signal Transduct Target Ther. 2022 03 24; 7(1):95.

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Juskeviciute E, Dippold RP, Antony AN, Swarup A, Vadigepalli R, Hoek JB. Inhibition of miR-21 rescues liver regeneration after partial hepatectomy in ethanol-fed rats. Am J Physiol Gastrointest Liver Physiol. 2016 Nov 01; 311(5):G794-G806.

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Illa-Bochaca I, Ouyang H, Tang J, Sebastiano C, Mao JH, Costes SV, Demaria S, Barcellos-Hoff MH. Densely ionizing radiation acts via the microenvironment to promote aggressive Trp53-null mammary carcinomas. Cancer Res. 2014 Dec 01; 74(23):7137-48.

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South AP, Purdie KJ, Watt SA, Haldenby S, den Breems NY, Dimon M, Arron ST, Kluk MJ, Aster JC, McHugh A, Xue DJ, Dayal JH, Robinson KS, Rizvi SM, Proby CM, Harwood CA, Leigh IM. NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis. J Invest Dermatol. 2014 Oct; 134(10):2630-8.

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Domingo-Domenech J, Vidal SJ, Rodriguez-Bravo V, Castillo-Martin M, Quinn SA, Rodriguez-Barrueco R, Bonal DM, Charytonowicz E, Gladoun N, de la Iglesia-Vicente J, Petrylak DP, Benson MC, Silva JM, Cordon-Cardo C. Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cells. Cancer Cell. 2012 Sep 11; 22(3):373-88.

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Scott AP, Laing NG, Mastaglia F, Dalakas M, Needham M, Allcock RJ. Investigation of NOTCH4 coding region polymorphisms in sporadic inclusion body myositis. J Neuroimmunol. 2012 Sep 15; 250(1-2):66-70.

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Debeb BG, Cohen EN, Boley K, Freiter EM, Li L, Robertson FM, Reuben JM, Cristofanilli M, Buchholz TA, Woodward WA. Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cells. Breast Cancer Res Treat. 2012 Jul; 134(2):495-510.

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Fortini ME. Introduction--Notch in development and disease. Semin Cell Dev Biol. 2012 Jun; 23(4):419-20.

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Groth C, Fortini ME. Therapeutic approaches to modulating Notch signaling: current challenges and future prospects. Semin Cell Dev Biol. 2012 Jun; 23(4):465-72.

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South AP, Cho RJ, Aster JC. The double-edged sword of Notch signaling in cancer. Semin Cell Dev Biol. 2012 Jun; 23(4):458-64.

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