DNA-Directed DNA Polymerase
"DNA-Directed DNA Polymerase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
| Descriptor ID |
D004259
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| MeSH Number(s) |
D08.811.913.696.445.308.300
|
| Concept/Terms |
DNA-Directed DNA Polymerase- DNA-Directed DNA Polymerase
- DNA Directed DNA Polymerase
- DNA Polymerase, DNA-Directed
- Polymerase, DNA-Directed DNA
- DNA-Dependent DNA Polymerases
- DNA Dependent DNA Polymerases
- DNA Polymerases, DNA-Dependent
- Polymerases, DNA-Dependent DNA
- DNA Polymerases
- Polymerases, DNA
|
Below are MeSH descriptors whose meaning is more general than "DNA-Directed DNA Polymerase".
Below are MeSH descriptors whose meaning is more specific than "DNA-Directed DNA Polymerase".
This graph shows the total number of publications written about "DNA-Directed DNA Polymerase" by people in this website by year, and whether "DNA-Directed DNA Polymerase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 1 | 1 | 2 |
| 2005 | 2 | 0 | 2 |
| 2006 | 2 | 2 | 4 |
| 2008 | 1 | 1 | 2 |
| 2009 | 3 | 0 | 3 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 1 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 2 | 0 | 2 |
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Below are the most recent publications written about "DNA-Directed DNA Polymerase" by people in Profiles.
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Black SJ, Ozdemir AY, Kashkina E, Kent T, Rusanov T, Ristic D, Shin Y, Suma A, Hoang T, Chandramouly G, Siddique LA, Borisonnik N, Sullivan-Reed K, Mallon JS, Skorski T, Carnevale V, Murakami KS, Wyman C, Pomerantz RT. Molecular basis of microhomology-mediated end-joining by purified full-length Pol?. Nat Commun. 2019 09 27; 10(1):4423.
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Thomas C, Rusanov T, Hoang T, Augustin T, Kent T, Gaspar I, Pomerantz RT. One-step enzymatic modification of RNA 3' termini using polymerase ?. Nucleic Acids Res. 2019 04 23; 47(7):3272-3283.
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Ozdemir AY, Rusanov T, Kent T, Siddique LA, Pomerantz RT. Polymerase ?-helicase efficiently unwinds DNA and RNA-DNA hybrids. J Biol Chem. 2018 04 06; 293(14):5259-5269.
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Mateos-Gomez PA, Kent T, Deng SK, McDevitt S, Kashkina E, Hoang TM, Pomerantz RT, Sfeir A. The helicase domain of Pol? counteracts RPA to promote alt-NHEJ. Nat Struct Mol Biol. 2017 Dec; 24(12):1116-1123.
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Kent T, Rusanov TD, Hoang TM, Velema WA, Krueger AT, Copeland WC, Kool ET, Pomerantz RT. DNA polymerase ? specializes in incorporating synthetic expanded-size (xDNA) nucleotides. Nucleic Acids Res. 2016 Nov 02; 44(19):9381-9392.
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Kent T, Mateos-Gomez PA, Sfeir A, Pomerantz RT. Polymerase ? is a robust terminal transferase that oscillates between three different mechanisms during end-joining. Elife. 2016 06 17; 5.
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Kent T, Chandramouly G, McDevitt SM, Ozdemir AY, Pomerantz RT. Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase ?. Nat Struct Mol Biol. 2015 Mar; 22(3):230-7.
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Joshi A, Zhao B, Romanowski C, Rosen D, Flomenberg P. Comparison of human memory CD8 T cell responses to adenoviral early and late proteins in peripheral blood and lymphoid tissue. PLoS One. 2011; 6(5):e20068.
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Ai Y, Wang J, Johnson RE, Haracska L, Prakash L, Zhuang Z. A novel ubiquitin binding mode in the S. cerevisiae translesion synthesis DNA polymerase ?. Mol Biosyst. 2011 Jun; 7(6):1874-82.
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Mason AC, Roy R, Simmons DT, Wold MS. Functions of alternative replication protein A in initiation and elongation. Biochemistry. 2010 Jul 20; 49(28):5919-28.