"Checkpoint Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzyme activated in response to DNA DAMAGE involved in cell cycle arrest. The gene is located on the long (q) arm of chromosome 22 at position 12.1. In humans it is encoded by the CHEK2 gene.
| Descriptor ID |
D064447
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.145
|
| Concept/Terms |
Checkpoint Kinase 2- Checkpoint Kinase 2
- Kinase 2, Checkpoint
- Chk2 Protein Kinase
- Kinase, Chk2 Protein
- Protein Kinase, Chk2
- Checkpoint-Like Protein CHK2
- CHK2, Checkpoint-Like Protein
- Checkpoint Like Protein CHK2
- Protein CHK2, Checkpoint-Like
- Serine Threonine Protein Kinase Chk2
- LFS2 Protein Kinase
- Kinase, LFS2 Protein
- Protein Kinase, LFS2
- CHEK2 Kinase
- Kinase, CHEK2
- hCHK2 Kinase
- Kinase, hCHK2
- Serine-Threonine-Protein Kinase CHK2
- CHK2, Serine-Threonine-Protein Kinase
- Kinase CHK2, Serine-Threonine-Protein
- CDS1 Kinase
- Kinase, CDS1
- PP1425 Protein Kinase
- Kinase, PP1425 Protein
- Protein Kinase, PP1425
|
Below are MeSH descriptors whose meaning is more general than "Checkpoint Kinase 2".
Below are MeSH descriptors whose meaning is more specific than "Checkpoint Kinase 2".
This graph shows the total number of publications written about "Checkpoint Kinase 2" by people in this website by year, and whether "Checkpoint Kinase 2" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2013 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Checkpoint Kinase 2" by people in Profiles.
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Nie X, Guo E, Wu C, Liu D, Sun W, Zhang L, Long G, Mei Q, Wu K, Xiong H, Hu G. SALL4 induces radioresistance in nasopharyngeal carcinoma via the ATM/Chk2/p53 pathway. Cancer Med. 2019 04; 8(4):1779-1792.
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Minion LE, Dolinsky JS, Chase DM, Dunlop CL, Chao EC, Monk BJ. Hereditary predisposition to ovarian cancer, looking beyond BRCA1/BRCA2. Gynecol Oncol. 2015 Apr; 137(1):86-92.
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Mendoza J, Sekiya M, Taniguchi T, Iijima KM, Wang R, Ando K. Global analysis of phosphorylation of tau by the checkpoint kinases Chk1 and Chk2 in vitro. J Proteome Res. 2013 Jun 07; 12(6):2654-65.
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Iijima K, Gatt A, Iijima-Ando K. Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease. Hum Mol Genet. 2010 Aug 01; 19(15):2947-57.
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Iijima-Ando K, Zhao L, Gatt A, Shenton C, Iijima K. A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration. Hum Mol Genet. 2010 May 15; 19(10):1930-8.
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Sun J, Okumura H, Yearsley M, Frankel W, Fong LY, Druck T, Huebner K. Nit1 and Fhit tumor suppressor activities are additive. J Cell Biochem. 2009 Aug 15; 107(6):1097-106.
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Choi DH, Cho DY, Lee MH, Park HS, Ahn SH, Son BH, Haffty BG. The CHEK2 1100delC mutation is not present in Korean patients with breast cancer cases tested for BRCA1 and BRCA2 mutation. Breast Cancer Res Treat. 2008 Dec; 112(3):569-73.
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Huang J, Domchek SM, Brose MS, Rebbeck TR, Nathanson KL, Weber BL. Germline CHEK2*1100delC mutations in breast cancer patients with multiple primary cancers. J Med Genet. 2004 Nov; 41(11):e120.
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Routhier EL, Donover PS, Prendergast GC. hob1+, the fission yeast homolog of Bin1, is dispensable for endocytosis or actin organization, but required for the response to starvation or genotoxic stress. Oncogene. 2003 Feb 06; 22(5):637-48.