"Activin Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity.
| Descriptor ID |
D029404
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.062 D12.776.543.750.750.400.820.500
|
| Concept/Terms |
Activin Receptors- Activin Receptors
- Receptor, Activin
- Activin Receptor-Like Kinases
- Activin Receptor like Kinases
- Kinases, Activin Receptor-like
- Receptor-like Kinases, Activin
- Activin Receptor
- Activin Receptor-like Kinase
- Activin Receptor like Kinase
- Kinase, Activin Receptor-like
- Receptor-like Kinase, Activin
|
Below are MeSH descriptors whose meaning is more general than "Activin Receptors".
Below are MeSH descriptors whose meaning is more specific than "Activin Receptors".
This graph shows the total number of publications written about "Activin Receptors" by people in this website by year, and whether "Activin Receptors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Activin Receptors" by people in Profiles.
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Yu XM, Gutman I, Mosca TJ, Iram T, Ozkan E, Garcia KC, Luo L, Schuldiner O. Plum, an immunoglobulin superfamily protein, regulates axon pruning by facilitating TGF-? signaling. Neuron. 2013 May 08; 78(3):456-68.
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Daluiski A, Engstrand T, Bahamonde ME, Gamer LW, Agius E, Stevenson SL, Cox K, Rosen V, Lyons KM. Bone morphogenetic protein-3 is a negative regulator of bone density. Nat Genet. 2001 Jan; 27(1):84-8.
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He ZY, Liu HC, Mele CA, Barmat L, Veeck LL, Davis O, Rosenwaks Z. Expression of inhibin/activin subunits and their receptors and binding proteins in human preimplantation embryos. J Assist Reprod Genet. 1999 Feb; 16(2):73-80.
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Goggins M, Shekher M, Turnacioglu K, Yeo CJ, Hruban RH, Kern SE. Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res. 1998 Dec 01; 58(23):5329-32.