3-Phosphoinositide-Dependent Protein Kinases

"3-Phosphoinositide-Dependent Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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Highly conserved protein-serine threonine kinases that phosphorylate and activate a group of AGC protein kinases, especially in response to the production of the SECOND MESSENGERS, phosphatidylinositol 3,4,-biphosphate (PtdIns(3,4)P2) and phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3).

Descriptor ID	D064413
MeSH Number(s)	D08.811.913.696.620.682.700.745
Concept/Terms	3-Phosphoinositide-Dependent Protein Kinases 3-Phosphoinositide-Dependent Protein Kinases 3 Phosphoinositide Dependent Protein Kinases Kinases, 3-Phosphoinositide-Dependent Protein Protein Kinases, 3-Phosphoinositide-Dependent 3-Phosphoinositide-Dependent Protein Kinase 3 Phosphoinositide Dependent Protein Kinase Kinase, 3-Phosphoinositide-Dependent Protein Protein Kinase, 3-Phosphoinositide-Dependent 3-Phosphoinositide Dependent Protein Kinase-1 3-Phosphoinositide Dependent Protein Kinase-1 3 Phosphoinositide Dependent Protein Kinase 1 3-Phosphoinositide-Dependent Protein Kinase-1 Kinase-1, 3-Phosphoinositide-Dependent Protein Protein Kinase-1, 3-Phosphoinositide-Dependent PtdIns(3,4,5)P3-Dependent Protein Kinase-1 3-Phosphoinositide-Dependent Kinase 1 (PDK1) 3-Phosphoinositide Dependent Protein Kinase-2 3-Phosphoinositide Dependent Protein Kinase-2 3 Phosphoinositide Dependent Protein Kinase 2 3-Phosphoinositide-Dependent Protein Kinase-2 Kinase-2, 3-Phosphoinositide-Dependent Protein Protein Kinase-2, 3-Phosphoinositide-Dependent

Below are MeSH descriptors whose meaning is more general than "3-Phosphoinositide-Dependent Protein Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
3-Phosphoinositide-Dependent Protein Kinases [D08.811.913.696.620.682.700.745]

Below are MeSH descriptors whose meaning is related to "3-Phosphoinositide-Dependent Protein Kinases".

Below are MeSH descriptors whose meaning is more specific than "3-Phosphoinositide-Dependent Protein Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "3-Phosphoinositide-Dependent Protein Kinases" by people in this website by year, and whether "3-Phosphoinositide-Dependent Protein Kinases" was a major or minor topic of these publications.

Bar chart showing 8 publications over 7 distinct years, with a maximum of 2 publications in 2013

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
2001	1	1
2002	1	1
2007	1	1
2009	1	1
2011	1	1
2013	2	2
2022	1	1

Below are the most recent publications written about "3-Phosphoinositide-Dependent Protein Kinases" by people in Profiles.

Cai W, Nguyen MQ, Wilski NA, Purwin TJ, Vernon M, Tiago M, Aplin AE. A Genome-Wide Screen Identifies PDPK1 as a Target to Enhance the Efficacy of MEK1/2 Inhibitors in NRAS Mutant Melanoma. Cancer Res. 2022 07 18; 82(14):2625-2639.

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Manterola L, Hernando-Rodr?guez M, Ruiz A, Apraiz A, Arrizabalaga O, Vell?n L, Alberdi E, Cavaliere F, Lacerda HM, Jimenez S, Parada LA, Matute C, Zugaza JL. 1-42 ?-amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death. Transl Psychiatry. 2013 Jan 22; 3:e219.

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Shen D, Bai M, Tang R, Xu B, Ju X, Pestell RG, Achilefu S. Dual fluorescent molecular substrates selectively report the activation, sustainability and reversibility of cellular PKB/Akt activity. Sci Rep. 2013; 3:1697.

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Borland MG, Khozoie C, Albrecht PP, Zhu B, Lee C, Lahoti TS, Gonzalez FJ, Peters JM. Stable over-expression of PPAR?/d and PPAR? to examine receptor signaling in human HaCaT keratinocytes. Cell Signal. 2011 Dec; 23(12):2039-50.

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Rodriguez OC, Lai EW, Vissapragada S, Cromelin C, Avetian M, Salinas P, Ramos H, Kallakury B, Casimiro M, Lisanti MP, Tanowitz HB, Pacak K, Glazer RI, Avantaggiati M, Albanese C. A reduction in Pten tumor suppressor activity promotes ErbB-2-induced mouse prostate adenocarcinoma formation through the activation of signaling cascades downstream of PDK1. Am J Pathol. 2009 Jun; 174(6):2051-60.

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Burdick AD, Bility MT, Girroir EE, Billin AN, Willson TM, Gonzalez FJ, Peters JM. Ligand activation of peroxisome proliferator-activated receptor-beta/delta(PPARbeta/delta) inhibits cell growth of human N/TERT-1 keratinocytes. Cell Signal. 2007 Jun; 19(6):1163-71.

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Yin Y, Yuan H, Wang C, Pattabiraman N, Rao M, Pestell RG, Glazer RI. 3-phosphoinositide-dependent protein kinase-1 activates the peroxisome proliferator-activated receptor-gamma and promotes adipocyte differentiation. Mol Endocrinol. 2006 Feb; 20(2):268-78.

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Perez OD, Kinoshita S, Hitoshi Y, Payan DG, Kitamura T, Nolan GP, Lorens JB. Activation of the PKB/AKT pathway by ICAM-2. Immunity. 2002 Jan; 16(1):51-65.

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Chan TO, Tsichlis PN. PDK2: a complex tail in one Akt. Sci STKE. 2001 Jan 23; 2001(66):pe1.

View in: PubMed

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