"Platelet Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.
| Descriptor ID |
D010978
|
| MeSH Number(s) |
D12.644.276.374.200.120.900 D12.776.124.125.720 D12.776.467.374.200.120.900 D23.119.940 D23.125.300.120.900 D23.469.200.120.900 D23.529.374.200.120.900
|
| Concept/Terms |
Platelet Factor 4- Platelet Factor 4
- Chemokine CXCL4
- CXCL4, Chemokine
- PF4 (Platelet Factor 4)
- gamma-Thromboglobulin
- gamma Thromboglobulin
- Heparin Neutralizing Protein
- Antiheparin Factor
- CXCL4 Chemokine
- Chemokine, CXCL4
|
Below are MeSH descriptors whose meaning is more general than "Platelet Factor 4".
Below are MeSH descriptors whose meaning is more specific than "Platelet Factor 4".
This graph shows the total number of publications written about "Platelet Factor 4" by people in this website by year, and whether "Platelet Factor 4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 0 | 2 | 2 |
| 2012 | 1 | 0 | 1 |
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Below are the most recent publications written about "Platelet Factor 4" by people in Profiles.
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McKenzie SE. Monocytes in HIT: an evolving story. Blood. 2012 May 31; 119(22):5065-6.
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Woulfe DS, Lilliendahl JK, August S, Rauova L, Kowalska MA, Abrink M, Pejler G, White JG, Schick BP. Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice. Blood. 2008 Apr 01; 111(7):3458-67.
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Cines DB, Rauova L, Arepally G, Reilly MP, McKenzie SE, Sachais BS, Poncz M. Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly. J Clin Apher. 2007 Feb; 22(1):31-6.
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Suvarna S, Rauova L, McCracken EK, Goss CM, Sachais BS, McKenzie SE, Reilly MP, Gunn MD, Cines DB, Poncz M, Arepally G. PF4/heparin complexes are T cell-dependent antigens. Blood. 2005 Aug 1; 106(3):929-31.
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Rauova L, Poncz M, McKenzie SE, Reilly MP, Arepally G, Weisel JW, Nagaswami C, Cines DB, Sachais BS. Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. Blood. 2005 Jan 1; 105(1):131-8.
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Reilly MP, McKenzie SE. Insights from mouse models of heparin-induced thrombocytopenia and thrombosis. Curr Opin Hematol. 2002 Sep; 9(5):395-400.
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Cui Z, Reilly MP, Surrey S, Schwartz E, McKenzie SE. -245 bp of 5'-flanking region from the human platelet factor 4 gene is sufficient to drive megakaryocyte-specific expression in vivo. Blood. 1998 Apr 01; 91(7):2326-33.
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Ramachandran B, Surrey S, Schwartz E. Megakaryocyte-specific positive regulatory sequence 5' to the human PF4 gene. Exp Hematol. 1995 Jan; 23(1):49-57.
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Eisman R, Surrey S, Ramachandran B, Schwartz E, Poncz M. Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. Blood. 1990 Jul 15; 76(2):336-44.
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Park KS, Rifat S, Eck H, Adachi K, Surrey S, Poncz M. Biologic and biochemic properties of recombinant platelet factor 4 demonstrate identity with the native protein. Blood. 1990 Mar 15; 75(6):1290-5.