Bcl-2-Like Protein 11

"Bcl-2-Like Protein 11" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A BCL-2-like protein that has a C-terminal BCL-2 homology (BH3) domain and forms heterodimers with other BCL-2 FAMILY PROTEINS. It is a strong inducer of APOPTOSIS and ANOIKIS; several isoforms are expressed (BimEL, Bim L, Bim-alpha, Bim-s; and Bim-gamma) that have different potencies for inducing apoptosis.

Descriptor ID	D000072224
MeSH Number(s)	D12.644.360.075.323 D12.776.476.075.323 D12.776.543.116 D12.776.624.664.700.025
Concept/Terms	Bcl-2-Like Protein 11 Bcl-2-Like Protein 11 11, Bcl-2-Like Protein Bcl 2 Like Protein 11 Protein 11, Bcl-2-Like Bcl-2-Interacting Mediator of Cell Death Bcl 2 Interacting Mediator of Cell Death Bcl-2-Binding Protein, BIM BIM Bcl-2-Binding Protein Bcl 2 Binding Protein, BIM Protein, BIM Bcl-2-Binding BCL2L11 Protein Protein, BCL2L11 BIM Protein Protein, BIM

Below are MeSH descriptors whose meaning is more general than "Bcl-2-Like Protein 11".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Apoptosis Regulatory Proteins [D12.644.360.075]
Bcl-2-Like Protein 11 [D12.644.360.075.323]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Apoptosis Regulatory Proteins [D12.776.476.075]
Bcl-2-Like Protein 11 [D12.776.476.075.323]
Membrane Proteins [D12.776.543]
Bcl-2-Like Protein 11 [D12.776.543.116]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
Bcl-2-Like Protein 11 [D12.776.624.664.700.025]

Below are MeSH descriptors whose meaning is related to "Bcl-2-Like Protein 11".

Below are MeSH descriptors whose meaning is more specific than "Bcl-2-Like Protein 11".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Bcl-2-Like Protein 11" by people in this website by year, and whether "Bcl-2-Like Protein 11" was a major or minor topic of these publications.

Bar chart showing 10 publications over 7 distinct years, with a maximum of 3 publications in 2010

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
2006	2	2
2007	1	1
2008	1	1
2010	3	3
2011	1	1
2012	1	1
2014	1	1

Below are the most recent publications written about "Bcl-2-Like Protein 11" by people in Profiles.

Fiskus W, Sharma S, Qi J, Valenta JA, Schaub LJ, Shah B, Peth K, Portier BP, Rodriguez M, Devaraj SG, Zhan M, Sheng J, Iyer SP, Bradner JE, Bhalla KN. Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myelogenous leukemia cells. Mol Cancer Ther. 2014 May; 13(5):1142-54.

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Shao Y, Aplin AE. BH3-only protein silencing contributes to acquired resistance to PLX4720 in human melanoma. Cell Death Differ. 2012 Dec; 19(12):2029-39.

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Stadanlick JE, Zhang Z, Lee SY, Hemann M, Biery M, Carleton MO, Zambetti GP, Anderson SJ, Oravecz T, Wiest DL. Developmental arrest of T cells in Rpl22-deficient mice is dependent upon multiple p53 effectors. J Immunol. 2011 Jul 15; 187(2):664-75.

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Miletic AV, Anzelon-Mills AN, Mills DM, Omori SA, Pedersen IM, Shin DM, Ravetch JV, Bolland S, Morse HC, Rickert RC. Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases. J Exp Med. 2010 Oct 25; 207(11):2407-20.

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Shao Y, Aplin AE. Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells. Cancer Res. 2010 Aug 15; 70(16):6670-81.

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Haenssen KK, Caldwell SA, Shahriari KS, Jackson SR, Whelan KA, Klein-Szanto AJ, Reginato MJ. ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells. J Cell Sci. 2010 Apr 15; 123(Pt 8):1373-82.

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Boisvert-Adamo K, Aplin AE. Mutant B-RAF mediates resistance to anoikis via Bad and Bim. Oncogene. 2008 May 22; 27(23):3301-12.

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Hetz C, Thielen P, Fisher J, Pasinelli P, Brown RH, Korsmeyer S, Glimcher L. The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis. Cell Death Differ. 2007 Jul; 14(7):1386-9.

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Quadros MR, Connelly S, Kari C, Abrams MT, Wickstrom E, Rodeck U. EGFR-dependent downregulation of Bim in epithelial cells requires MAPK and PKC-delta activities. Cancer Biol Ther. 2006 May; 5(5):498-504.

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Vogiatzi P, De Falco G, Claudio PP, Giordano A. How does the human RUNX3 gene induce apoptosis in gastric cancer? Latest data, reflections and reactions. Cancer Biol Ther. 2006 Apr; 5(4):371-4.

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