Calcineurin

"Calcineurin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.

Descriptor ID	D019703
MeSH Number(s)	D08.811.277.352.650.625.150 D12.644.360.087 D12.776.476.087
Concept/Terms	Calcineurin Calcineurin Protein Phosphatase 3 Phosphatase 3, Protein Protein Phosphatase-2B Protein Phosphatase 2B Calcineurin B Calcineurin B Protein Phosphatase 3 Regulatory Subunit Calcineurin A Calcineurin A Protein Phosphatase 3 Catalytic Subunit

Below are MeSH descriptors whose meaning is more general than "Calcineurin".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Monoester Hydrolases [D08.811.277.352.650]
Phosphoprotein Phosphatases [D08.811.277.352.650.625]
Calcineurin [D08.811.277.352.650.625.150]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Calcineurin [D12.644.360.087]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Calcineurin [D12.776.476.087]

Below are MeSH descriptors whose meaning is related to "Calcineurin".

Below are MeSH descriptors whose meaning is more specific than "Calcineurin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Calcineurin" by people in this website by year, and whether "Calcineurin" was a major or minor topic of these publications.

Bar chart showing 23 publications over 11 distinct years, with a maximum of 4 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	1	0	1
2003	2	2	4
2004	1	1	2
2005	3	0	3
2006	2	1	3
2007	2	1	3
2009	2	1	3
2010	0	1	1
2011	1	0	1
2018	1	0	1
2019	0	1	1

Below are the most recent publications written about "Calcineurin" by people in Profiles.

Tsay AJ, Eisen HJ. mTOR inhibitors vs calcineurin inhibitors: A Catch-22-preventing nephrotoxicity or acute allograft rejection after heart transplantation. Am J Transplant. 2019 11; 19(11):2967-2968.

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Rusmini P, Cortese K, Crippa V, Cristofani R, Cicardi ME, Ferrari V, Vezzoli G, Tedesco B, Meroni M, Messi E, Piccolella M, Galbiati M, Garr? M, Morelli E, Vaccari T, Poletti A. Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration. Autophagy. 2019 04; 15(4):631-651.

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Fernandez AM, Jimenez S, Mecha M, D?vila D, Guaza C, Vitorica J, Torres-Aleman I. Regulation of the phosphatase calcineurin by insulin-like growth factor I unveils a key role of astrocytes in Alzheimer's pathology. Mol Psychiatry. 2012 Jul; 17(7):705-18.

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Chen X, Nakayama H, Zhang X, Ai X, Harris DM, Tang M, Zhang H, Szeto C, Stockbower K, Berretta RM, Eckhart AD, Koch WJ, Molkentin JD, Houser SR. Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy. J Mol Cell Cardiol. 2011 Mar; 50(3):460-70.

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Charavaryamath C, Lemieux H, Singh Suri S, Selvakumar P, Sharma RK, Singh B. Expression and activities of N-myristoyltransferase and calcineurin in normal and inflamed lungs. Exp Lung Res. 2009 Nov; 35(9):729-47.

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Kolwicz SC, MacDonnell SM, Renna BF, Reger PO, Seqqat R, Rafiq K, Kendrick ZV, Houser SR, Sabri A, Libonati JR. Left ventricular remodeling with exercise in hypertension. Am J Physiol Heart Circ Physiol. 2009 Oct; 297(4):H1361-8.

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Zuo Y, Selvakumar P, Sharma RK. Molecular cloning and biochemical characterization of bovine retina calcineurin. Mol Cell Biochem. 2010 Jan; 333(1-2):73-82.

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Lakshmikuttyamma A, Selvakumar P, Tuchek J, Sharma RK. Myristoyltransferase and calcineurin: novel molecular therapeutic target for epilepsy. Prog Neurobiol. 2008 Jan; 84(1):77-84.

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MacDonnell SM, Kubo H, Harris DM, Chen X, Berretta R, Barbe MF, Kolwicz S, Reger PO, Eckhart A, Renna BF, Koch WJ, Houser SR, Libonati JR. Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H3122-9.

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Hand BD, Kostek MC, Ferrell RE, Delmonico MJ, Douglass LW, Roth SM, Hagberg JM, Hurley BF. Influence of promoter region variants of insulin-like growth factor pathway genes on the strength-training response of muscle phenotypes in older adults. J Appl Physiol (1985). 2007 Nov; 103(5):1678-87.

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