Calcineurin

"Calcineurin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.

Descriptor ID	D019703
MeSH Number(s)	D08.811.277.352.650.625.150 D12.644.360.087 D12.776.476.087
Concept/Terms	Calcineurin Calcineurin Protein Phosphatase 3 Phosphatase 3, Protein Protein Phosphatase-2B Protein Phosphatase 2B Calcineurin B Calcineurin B Protein Phosphatase 3 Regulatory Subunit Calcineurin A Calcineurin A Protein Phosphatase 3 Catalytic Subunit

Below are MeSH descriptors whose meaning is more general than "Calcineurin".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Monoester Hydrolases [D08.811.277.352.650]
Phosphoprotein Phosphatases [D08.811.277.352.650.625]
Calcineurin [D08.811.277.352.650.625.150]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Calcineurin [D12.644.360.087]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Calcineurin [D12.776.476.087]

Below are MeSH descriptors whose meaning is related to "Calcineurin".

Below are MeSH descriptors whose meaning is more specific than "Calcineurin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Calcineurin" by people in this website by year, and whether "Calcineurin" was a major or minor topic of these publications.

Bar chart showing 20 publications over 9 distinct years, with a maximum of 4 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	2	1	3
2004	1	1	2
2005	3	0	3
2006	2	2	4
2007	1	1	2
2008	0	1	1
2009	2	1	3
2012	0	1	1
2019	0	1	1

Below are the most recent publications written about "Calcineurin" by people in Profiles.

Tsay AJ, Eisen HJ. mTOR inhibitors vs calcineurin inhibitors: A Catch-22-preventing nephrotoxicity or acute allograft rejection after heart transplantation. Am J Transplant. 2019 11; 19(11):2967-2968.

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del Blanco B, Garc?a-Mariscal A, Wiest DL, Hern?ndez-Munain C. Tcra enhancer activation by inducible transcription factors downstream of pre-TCR signaling. J Immunol. 2012 Apr 01; 188(7):3278-93.

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Charavaryamath C, Lemieux H, Singh Suri S, Selvakumar P, Sharma RK, Singh B. Expression and activities of N-myristoyltransferase and calcineurin in normal and inflamed lungs. Exp Lung Res. 2009 Nov; 35(9):729-47.

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Kolwicz SC, MacDonnell SM, Renna BF, Reger PO, Seqqat R, Rafiq K, Kendrick ZV, Houser SR, Sabri A, Libonati JR. Left ventricular remodeling with exercise in hypertension. Am J Physiol Heart Circ Physiol. 2009 Oct; 297(4):H1361-8.

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Zuo Y, Selvakumar P, Sharma RK. Molecular cloning and biochemical characterization of bovine retina calcineurin. Mol Cell Biochem. 2010 Jan; 333(1-2):73-82.

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Aizu T, Tamai K, Nakano H, Rokunohe D, Toyomaki Y, Uitto J, Sawamura D. Calcineurin/NFAT-dependent regulation of 230-kDa bullous pemphigoid antigen (BPAG1) gene expression in normal human epidermal keratinocytes. J Dermatol Sci. 2008 Jul; 51(1):45-51.

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Lakshmikuttyamma A, Selvakumar P, Tuchek J, Sharma RK. Myristoyltransferase and calcineurin: novel molecular therapeutic target for epilepsy. Prog Neurobiol. 2008 Jan; 84(1):77-84.

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Hand BD, Kostek MC, Ferrell RE, Delmonico MJ, Douglass LW, Roth SM, Hagberg JM, Hurley BF. Influence of promoter region variants of insulin-like growth factor pathway genes on the strength-training response of muscle phenotypes in older adults. J Appl Physiol (1985). 2007 Nov; 103(5):1678-87.

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Knickelbein JE, de Souza AJ, Tosti R, Narayan P, Kane LP. Cutting edge: inhibition of T cell activation by TIM-2. J Immunol. 2006 Oct 15; 177(8):4966-70.

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Selvakumar P, Sharma RK. Phosphorylation and dephosphorylation of human myristoyltransferase type 1. Can J Physiol Pharmacol. 2006 Jul; 84(7):707-12.

View in: PubMed

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