Calcineurin

"Calcineurin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.

Descriptor ID	D019703
MeSH Number(s)	D08.811.277.352.650.625.150 D12.644.360.087 D12.776.476.087
Concept/Terms	Calcineurin Calcineurin Protein Phosphatase 3 Phosphatase 3, Protein Protein Phosphatase-2B Protein Phosphatase 2B Calcineurin B Calcineurin B Protein Phosphatase 3 Regulatory Subunit Calcineurin A Calcineurin A Protein Phosphatase 3 Catalytic Subunit

Below are MeSH descriptors whose meaning is more general than "Calcineurin".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Monoester Hydrolases [D08.811.277.352.650]
Phosphoprotein Phosphatases [D08.811.277.352.650.625]
Calcineurin [D08.811.277.352.650.625.150]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Calcineurin [D12.644.360.087]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Calcineurin [D12.776.476.087]

Below are MeSH descriptors whose meaning is related to "Calcineurin".

Below are MeSH descriptors whose meaning is more specific than "Calcineurin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Calcineurin" by people in this website by year, and whether "Calcineurin" was a major or minor topic of these publications.

Bar chart showing 28 publications over 14 distinct years, with a maximum of 4 publications in 2003 and 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	2	0	2
2003	2	2	4
2004	1	1	2
2005	3	0	3
2006	2	2	4
2007	2	1	3
2008	0	1	1
2009	2	1	3
2010	0	1	1
2011	1	0	1
2012	0	1	1
2017	1	0	1
2018	1	0	1
2019	0	1	1

Below are the most recent publications written about "Calcineurin" by people in Profiles.

Tsay AJ, Eisen HJ. mTOR inhibitors vs calcineurin inhibitors: A Catch-22-preventing nephrotoxicity or acute allograft rejection after heart transplantation. Am J Transplant. 2019 11; 19(11):2967-2968.

View in: PubMed
Rusmini P, Cortese K, Crippa V, Cristofani R, Cicardi ME, Ferrari V, Vezzoli G, Tedesco B, Meroni M, Messi E, Piccolella M, Galbiati M, Garr? M, Morelli E, Vaccari T, Poletti A. Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration. Autophagy. 2019 04; 15(4):631-651.

View in: PubMed
Zemel BM, Muqeem T, Brown EV, Goul?o M, Urban MW, Tymanskyj SR, Lepore AC, Covarrubias M. Calcineurin Dysregulation Underlies Spinal Cord Injury-Induced K+ Channel Dysfunction in DRG Neurons. J Neurosci. 2017 08 23; 37(34):8256-8272.

View in: PubMed
del Blanco B, Garc?a-Mariscal A, Wiest DL, Hern?ndez-Munain C. Tcra enhancer activation by inducible transcription factors downstream of pre-TCR signaling. J Immunol. 2012 Apr 01; 188(7):3278-93.

View in: PubMed
Fernandez AM, Jimenez S, Mecha M, D?vila D, Guaza C, Vitorica J, Torres-Aleman I. Regulation of the phosphatase calcineurin by insulin-like growth factor I unveils a key role of astrocytes in Alzheimer's pathology. Mol Psychiatry. 2012 Jul; 17(7):705-18.

View in: PubMed
Chen X, Nakayama H, Zhang X, Ai X, Harris DM, Tang M, Zhang H, Szeto C, Stockbower K, Berretta RM, Eckhart AD, Koch WJ, Molkentin JD, Houser SR. Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy. J Mol Cell Cardiol. 2011 Mar; 50(3):460-70.

View in: PubMed
Charavaryamath C, Lemieux H, Singh Suri S, Selvakumar P, Sharma RK, Singh B. Expression and activities of N-myristoyltransferase and calcineurin in normal and inflamed lungs. Exp Lung Res. 2009 Nov; 35(9):729-47.

View in: PubMed
Kolwicz SC, MacDonnell SM, Renna BF, Reger PO, Seqqat R, Rafiq K, Kendrick ZV, Houser SR, Sabri A, Libonati JR. Left ventricular remodeling with exercise in hypertension. Am J Physiol Heart Circ Physiol. 2009 Oct; 297(4):H1361-8.

View in: PubMed
Zuo Y, Selvakumar P, Sharma RK. Molecular cloning and biochemical characterization of bovine retina calcineurin. Mol Cell Biochem. 2010 Jan; 333(1-2):73-82.

View in: PubMed
Aizu T, Tamai K, Nakano H, Rokunohe D, Toyomaki Y, Uitto J, Sawamura D. Calcineurin/NFAT-dependent regulation of 230-kDa bullous pemphigoid antigen (BPAG1) gene expression in normal human epidermal keratinocytes. J Dermatol Sci. 2008 Jul; 51(1):45-51.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement