Receptor-Interacting Protein Serine-Threonine Kinases

"Receptor-Interacting Protein Serine-Threonine Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of serine-threonine kinases that plays a role in intracellular signal transduction by interacting with a variety of signaling adaptor proteins such as CRADD SIGNALING ADAPTOR PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; and TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN. Although they were initially described as death domain-binding adaptor proteins, members of this family may contain other protein-binding domains such as those involving caspase activation and recruitment.

Descriptor ID	D053422
MeSH Number(s)	D08.811.913.696.620.682.700.801 D12.644.360.024.285.400 D12.644.360.024.500.186 D12.644.360.075.421.400 D12.776.157.057.018.400 D12.776.157.057.500.186 D12.776.476.024.320.662 D12.776.476.024.500.186 D12.776.476.075.421.400
Concept/Terms	Receptor-Interacting Protein Serine-Threonine Kinases Receptor-Interacting Protein Serine-Threonine Kinases Receptor Interacting Protein Serine Threonine Kinases RIP Serine-Threonine Kinases Kinases, RIP Serine-Threonine RIP Serine Threonine Kinases Serine-Threonine Kinases, RIP Receptor-Interacting Protein Serine-Threonine Kinase 3 Receptor-Interacting Protein Serine-Threonine Kinase 3 Receptor Interacting Protein Serine Threonine Kinase 3 Receptor-Interacting Protein Serine-Threonine Kinase 1 Receptor-Interacting Protein Serine-Threonine Kinase 1 Receptor Interacting Protein Serine Threonine Kinase 1 Receptor Interacting Protein RIP RIP Serine-Threonine Kinase Kinase, RIP Serine-Threonine RIP Serine Threonine Kinase Serine-Threonine Kinase, RIP RIP (Receptor Interacting Protein)

Below are MeSH descriptors whose meaning is more general than "Receptor-Interacting Protein Serine-Threonine Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Receptor-Interacting Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700.801]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Death Domain Receptor Signaling Adaptor Proteins [D12.644.360.024.285]
Receptor-Interacting Protein Serine-Threonine Kinases [D12.644.360.024.285.400]
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins [D12.644.360.024.500]
Receptor-Interacting Protein Serine-Threonine Kinases [D12.644.360.024.500.186]
Apoptosis Regulatory Proteins [D12.644.360.075]
Death Domain Receptor Signaling Adaptor Proteins [D12.644.360.075.421]
Receptor-Interacting Protein Serine-Threonine Kinases [D12.644.360.075.421.400]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Death Domain Receptor Signaling Adaptor Proteins [D12.776.157.057.018]
Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.157.057.018.400]
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins [D12.776.157.057.500]
Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.157.057.500.186]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Death Domain Receptor Signaling Adaptor Proteins [D12.776.476.024.320]
Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.476.024.320.662]
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins [D12.776.476.024.500]
Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.476.024.500.186]
Apoptosis Regulatory Proteins [D12.776.476.075]
Death Domain Receptor Signaling Adaptor Proteins [D12.776.476.075.421]
Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.476.075.421.400]

Below are MeSH descriptors whose meaning is related to "Receptor-Interacting Protein Serine-Threonine Kinases".

Below are MeSH descriptors whose meaning is more specific than "Receptor-Interacting Protein Serine-Threonine Kinases".

Receptor-Interacting Protein Serine-Threonine Kinases
Receptor-Interacting Protein Serine-Threonine Kinase 2

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptor-Interacting Protein Serine-Threonine Kinases" by people in this website by year, and whether "Receptor-Interacting Protein Serine-Threonine Kinases" was a major or minor topic of these publications.

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2000	0	1	1
2013	1	1	2
2016	1	0	1
2019	1	0	1

Below are the most recent publications written about "Receptor-Interacting Protein Serine-Threonine Kinases" by people in Profiles.

Ingram JP, Thapa RJ, Fisher A, Tummers B, Zhang T, Yin C, Rodriguez DA, Guo H, Lane R, Williams R, Slifker MJ, Basagoudanavar SH, Rall GF, Dillon CP, Green DR, Kaiser WJ, Balachandran S. ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1. J Immunol. 2019 09 01; 203(5):1348-1355.

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Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S. DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death. Cell Host Microbe. 2016 Nov 09; 20(5):674-681.

View in: PubMed
Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S. Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):E3109-18.

View in: PubMed
Sanna-Cherchi S, Sampogna RV, Papeta N, Burgess KE, Nees SN, Perry BJ, Choi M, Bodria M, Liu Y, Weng PL, Lozanovski VJ, Verbitsky M, Lugani F, Sterken R, Paragas N, Caridi G, Carrea A, Dagnino M, Materna-Kiryluk A, Santamaria G, Murtas C, Ristoska-Bojkovska N, Izzi C, Kacak N, Bianco B, Giberti S, Gigante M, Piaggio G, Gesualdo L, Vukic DK, Vukojevic K, Saraga-Babic M, Saraga M, Gucev Z, Allegri L, Latos-Bielenska A, Casu D, State M, Scolari F, Ravazzolo R, Kiryluk K, Al-Awqati Q, D'Agati VD, Drummond IA, Tasic V, Lifton RP, Ghiggeri GM, Gharavi AG. Mutations in DSTYK and dominant urinary tract malformations. N Engl J Med. 2013 Aug 15; 369(7):621-9.

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Poyet JL, Srinivasula SM, Lin JH, Fernandes-Alnemri T, Yamaoka S, Tsichlis PN, Alnemri ES. Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization. J Biol Chem. 2000 Dec 1; 275(48):37966-77.

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Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T, Alnemri ES. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res. 1997 Feb 15; 57(4):615-9.

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