Protein Phosphatase 2

"Protein Phosphatase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regulatory subunits. At least two genes encode isoforms of the protein phosphatase catalytic subunit, while several isoforms of regulatory subunits exist due to the presence of multiple genes and the alternative splicing of their mRNAs. Protein phosphatase 2 acts on a broad variety of cellular proteins and may play a role as a regulator of intracellular signaling processes.

Descriptor ID	D054648
MeSH Number(s)	D08.811.277.352.650.625.706 D12.644.360.583 D12.776.476.561
Concept/Terms	Protein Phosphatase 2 Protein Phosphatase 2 Protein Phosphatase-2A Protein Phosphatase 2A Protein Phosphatase 2, Catalytic Subunit, alpha Isoform Protein Phosphatase 2, Catalytic Subunit, alpha Isoform PPP2CA Phosphatase Phosphatase, PPP2CA Protein Phosphatase 2A, Catalytic Subunit, alpha Isoform Serine-Threonine-Protein Phosphatase 2A Catalytic Subunit alpha Isoform Serine Threonine Protein Phosphatase 2A Catalytic Subunit alpha Isoform Protein Phosphatase 2, Catalytic Subunit, beta Isoform Protein Phosphatase 2, Catalytic Subunit, beta Isoform Protein Phosphatase 2A, Catalytic Subunit, beta Isoform PPP2CB Phosphatase Phosphatase, PPP2CB Serine Threonine Protein Phosphatase 2A Catalytic Subunit beta Isoform Protein Phosphatase 2, Regulatory Subunit Protein Phosphatase 2, Regulatory Subunit Protein Phosphatase 2, Regulatory Subunit A, alpha Isoform Protein Phosphatase 2, Regulatory Subunit A, alpha Isoform Protein Phosphatase 2A, Regulatory Subunit A , alpha Isoform Protein Phosphatase 2, Regulatory Subunit B, alpha Isoform Protein Phosphatase 2, Regulatory Subunit B, alpha Isoform Protein Phosphatase 2A, Regulatory Subunit B, alpha Isoform Protein Phosphatase 2, Regulatory Subunit B, beta Isoform Protein Phosphatase 2, Regulatory Subunit B, beta Isoform Protein Phosphatase 2A, Regulatory Subunit B, beta Isoform Protein Phosphatase 2, Regulatory Subunit B, delta Isoform Protein Phosphatase 2, Regulatory Subunit B, delta Isoform Protein Phosphatase 2A, Regulatory Subunit B, delta Isoform Protein Phosphatase 2, Regulatory Subunit B, gamma Isoform Protein Phosphatase 2, Regulatory Subunit B, gamma Isoform Protein Phosphatase 2A, Regulatory Subunit B, gamma Isoform Protein Phosphatase 2, Catalytic Subunit Protein Phosphatase 2, Catalytic Subunit Protein Phosphatase 2, Regulatory Subunit A, beta Isoform Protein Phosphatase 2, Regulatory Subunit A, beta Isoform Protein Phosphatase 2A, Regulatory Subunit A, beta Isoform

Below are MeSH descriptors whose meaning is more general than "Protein Phosphatase 2".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Monoester Hydrolases [D08.811.277.352.650]
Phosphoprotein Phosphatases [D08.811.277.352.650.625]
Protein Phosphatase 2 [D08.811.277.352.650.625.706]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Protein Phosphatase 2 [D12.644.360.583]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Protein Phosphatase 2 [D12.776.476.561]

Below are MeSH descriptors whose meaning is related to "Protein Phosphatase 2".

Below are MeSH descriptors whose meaning is more specific than "Protein Phosphatase 2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Phosphatase 2" by people in this website by year, and whether "Protein Phosphatase 2" was a major or minor topic of these publications.

Bar chart showing 18 publications over 14 distinct years, with a maximum of 3 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	3	3
2004	0	1	1
2005	0	1	1
2006	0	1	1
2007	0	2	2
2008	1	0	1
2009	1	0	1
2010	1	0	1
2011	1	0	1
2013	1	0	1
2014	1	1	2
2016	0	1	1
2017	1	0	1
2021	1	0	1

Below are the most recent publications written about "Protein Phosphatase 2" by people in Profiles.

Kitazawa T, Matsui T, Katsuki S, Goto A, Akagi K, Hatano N, Tokumitsu H, Takeya K, Eto M. A temporal Ca2+ desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKß/PP2A pathways. Am J Physiol Cell Physiol. 2021 09 01; 321(3):C549-C558.

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Lee SJ, Rodriguez-Bravo V, Kim H, Datta S, Foley EA. The PP2AB56 phosphatase promotes the association of Cdc20 with APC/C in mitosis. J Cell Sci. 2017 May 15; 130(10):1760-1771.

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Richard NP, Pippa R, Cleary MM, Puri A, Tibbitts D, Mahmood S, Christensen DJ, Jeng S, McWeeney S, Look AT, Chang BH, Tyner JW, Vitek MP, Odero MD, Sears R, Agarwal A. Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia. Oncotarget. 2016 Dec 20; 7(51):84214-84227.

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Pippa R, Dominguez A, Christensen DJ, Moreno-Miralles I, Blanco-Prieto MJ, Vitek MP, Odero MD. Effect of FTY720 on the SET-PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity. Leukemia. 2014 Sep; 28(9):1915-8.

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Agarwal A, MacKenzie RJ, Pippa R, Eide CA, Oddo J, Tyner JW, Sears R, Vitek MP, Odero MD, Christensen DJ, Druker BJ. Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia. Clin Cancer Res. 2014 Apr 15; 20(8):2092-103.

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McCourt P, Gallo-Ebert C, Gonghong Y, Jiang Y, Nickels JT. PP2A(Cdc55) regulates G1 cyclin stability. Cell Cycle. 2013 Apr 15; 12(8):1201-10.

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Chan TO, Zhang J, Rodeck U, Pascal JM, Armen RS, Spring M, Dumitru CD, Myers V, Li X, Cheung JY, Feldman AM. Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):E1120-7.

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Trotta R, Ciarlariello D, Dal Col J, Mao H, Chen L, Briercheck E, Yu J, Zhang J, Perrotti D, Caligiuri MA. The PP2A inhibitor SET regulates granzyme B expression in human natural killer cells. Blood. 2011 Feb 24; 117(8):2378-84.

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McCourt PC, Morgan JM, Nickels JT. Stress-induced ceramide-activated protein phosphatase can compensate for loss of amphiphysin-like activity in Saccharomyces cerevisiae and functions to reinitiate endocytosis. J Biol Chem. 2009 May 01; 284(18):11930-41.

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Evans BJ, Wang Z, Mobley L, Khosravi D, Fujii N, Navenot JM, Peiper SC. Physical association of GPR54 C-terminal with protein phosphatase 2A. Biochem Biophys Res Commun. 2008 Dec 26; 377(4):1067-71.

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