"Protamines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
| Descriptor ID |
D011479
|
| MeSH Number(s) |
D12.776.660.750 D12.776.664.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Protamines".
Below are MeSH descriptors whose meaning is more specific than "Protamines".
This graph shows the total number of publications written about "Protamines" by people in this website by year, and whether "Protamines" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protamines" by people in Profiles.
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Malayaman SN, Entwistle JW, Boateng P, Wechsler AS, Persaud JM, Cohen JB, Kirklin JK, Nielsen VG. Carbon monoxide releasing molecule-2 improves coagulation in patient plasma in vitro following cardiopulmonary bypass. Blood Coagul Fibrinolysis. 2011 Jul; 22(5):362-8.
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Teruya J, Styler M. Management of factor XI inhibitor for cardiac intervention: successful treatment with immunosuppressive therapy and plasma exchange. Haemophilia. 2000 May; 6(3):158-61.
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Leone P, Janson CG, McPhee SJ, During MJ. Global CNS gene transfer for a childhood neurogenetic enzyme deficiency: Canavan disease. Curr Opin Mol Ther. 1999 Aug; 1(4):487-92.
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Weisz PB, Joullié MM, Hunter CM, Kumor KM, Zhang Z, Levine E, Macarak E, Weiner D, Barnathan ES. A basic compositional requirement of agents having heparin-like cell-modulating activities. Biochem Pharmacol. 1997 Jul 01; 54(1):149-57.
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Levy JH, Schwieger IM, Zaidan JR, Faraj BA, Weintraub WS. Evaluation of patients at risk for protamine reactions. J Thorac Cardiovasc Surg. 1989 Aug; 98(2):200-4.
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Rosenwasser RH, Garrido E, Freed MH, Shupak RC. Monitoring of activated clotting time during carotid endarterectomy: a preliminary report. Neurosurgery. 1981 Nov; 9(5):521-3.
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Brown JE, Kitchell BB, Bjornsson TD, Shand DG. The artifactual nature of heparin-induced drug protein-binding alterations. Clin Pharmacol Ther. 1981 Nov; 30(5):636-43.
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Keshgegian AA, Austin GE, Meltzer SM, Furth JJ. RNA polymerase isolated from bovine lymphosarcoma by sequential low- and high-salt extraction. Cancer Res. 1975 Feb; 35(2):310-5.
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Kaplan MM, Wiktor TJ, Maes RF, Campbell JB, Koprowski H. Effect of polyions on the infectivity of rabies virus in tissue culture: construction of a single-cycle growth curve. J Virol. 1967 Feb; 1(1):145-51.