Protein Kinase C

"Protein Kinase C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.

Descriptor ID	D011493
MeSH Number(s)	D08.811.913.696.620.682.700.725
Concept/Terms	Protein Kinase C Protein Kinase C Calcium-Activated Phospholipid-Dependent Kinase Calcium Activated Phospholipid Dependent Kinase Phospholipid-Dependent Kinase, Calcium-Activated PKC Serine-Threonine Kinase PKC Serine Threonine Kinase Serine-Threonine Kinase, PKC Calcium Phospholipid-Dependent Protein Kinase Calcium Phospholipid Dependent Protein Kinase Phospholipid-Sensitive Calcium-Dependent Protein Kinase Phospholipid Sensitive Calcium Dependent Protein Kinase Protein Kinase M Protein Kinase M

Below are MeSH descriptors whose meaning is more general than "Protein Kinase C".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Protein Kinase C [D08.811.913.696.620.682.700.725]

Below are MeSH descriptors whose meaning is related to "Protein Kinase C".

Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Kinase C" by people in this website by year, and whether "Protein Kinase C" was a major or minor topic of these publications.

Bar chart showing 71 publications over 22 distinct years, with a maximum of 6 publications in 2002 and 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	2	0	2
1998	1	2	3
1999	3	1	4
2000	2	0	2
2001	2	2	4
2002	5	1	6
2003	1	3	4
2004	3	0	3
2005	2	3	5
2006	1	3	4
2007	4	2	6
2008	0	4	4
2010	1	3	4
2011	1	2	3
2012	1	4	5
2014	1	2	3
2015	1	1	2
2017	1	0	1
2021	0	2	2
2022	0	2	2
2024	0	1	1

Below are the most recent publications written about "Protein Kinase C" by people in Profiles.

Hernandez-Lara MA, Richard J, Deshpande DA. Diacylglycerol kinase is a keystone regulator of signaling relevant to the pathophysiology of asthma. Am J Physiol Lung Cell Mol Physiol. 2024 07 01; 327(1):L3-L18.

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Okyere AD, Song J, Patwa V, Carter RL, Enjamuri N, Lucchese AM, Ibetti J, de Lucia C, Schumacher SM, Koch WJ, Cheung JY, Benovic JL, Tilley DG. Pepducin ICL1-9-Mediated ?2-Adrenergic Receptor-Dependent Cardiomyocyte Contractility Occurs in a Gi Protein/ROCK/PKD-Sensitive Manner. Cardiovasc Drugs Ther. 2023 04; 37(2):245-256.

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Eto M, Katsuki S, Ohashi M, Miyagawa Y, Tanaka Y, Takeya K, Kitazawa T. Possible roles of N- and C-terminal unstructured tails of CPI-17 in regulating Ca2+ sensitization force of smooth muscle. J Smooth Muscle Res. 2022; 58(0):22-33.

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Yadav SK, Sharma P, Shah SD, Panettieri RA, Kambayashi T, Penn RB, Deshpande DA. Autocrine regulation of airway smooth muscle contraction by diacylglycerol kinase. J Cell Physiol. 2022 01; 237(1):603-616.

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Walker JL, Wang W, Lin E, Romisher A, Bouchie MP, Bleaken B, Menko AS, Kukuruzinska MA. Specification of the patterning of a ductal tree during branching morphogenesis of the submandibular gland. Sci Rep. 2021 01 11; 11(1):330.

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Luo J, Busillo JM, Stumm R, Benovic JL. G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of ?-Arrestin. Mol Pharmacol. 2017 06; 91(6):554-566.

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O-Uchi J, Sorenson J, Jhun BS, Mishra J, Hurst S, Williams K, Sheu SS, Lopes CM. Isoform-specific dynamic translocation of PKC by a1-adrenoceptor stimulation in live cells. Biochem Biophys Res Commun. 2015 Sep 25; 465(3):464-70.

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Makadia HK, Anderson WD, Fey D, Sauter T, Schwaber JS, Vadigepalli R. Multiscale model of dynamic neuromodulation integrating neuropeptide-induced signaling pathway activity with membrane electrophysiology. Biophys J. 2015 Jan 06; 108(1):211-23.

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O-Uchi J, Rice JJ, Ruwald MH, Parks XX, Ronzier E, Moss AJ, Zareba W, Lopes CM. Impaired IKs channel activation by Ca(2+)-dependent PKC shows correlation with emotion/arousal-triggered events in LQT1. J Mol Cell Cardiol. 2015 Feb; 79:203-11.

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Tourdot BE, Conaway S, Niisuke K, Edelstein LC, Bray PF, Holinstat M. Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and Gq signaling axis. Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2644-50.

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