RNA-Binding Protein EWS

"RNA-Binding Protein EWS" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A ubiquitous hnRNP protein that contains an RNA RECOGNITION MOTIF and C-terminal ranBP2-type zinc finger. It localizes to the CELL NUCLEUS and CYTOPLASM and is expressed as different isoforms in various tissues, interacting with CALMODULIN and TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. Translocations that result in the formation of fusion proteins containing parts of RNA-binding protein EWS are associated with EWING SARCOMA.

Descriptor ID	D034802
MeSH Number(s)	D12.644.360.650 D12.776.157.142.750 D12.776.157.725.813.750.900 D12.776.476.650 D12.776.624.664.700.913 D12.776.664.962.813.750.900
Concept/Terms	RNA-Binding Protein EWS RNA-Binding Protein EWS EWS, RNA-Binding Protein RNA Binding Protein EWS EWSR1 Protein Protein, EWSR1 Ewing Sarcoma Breakpoint Region 1 Protein EWS Proto-Oncogene Protein EWS Proto Oncogene Protein Proto-Oncogene Protein, EWS Ewing Sarcoma Breakpointregion 1 Protein EWS RNA Binding Protein 1 EWS Protein

Below are MeSH descriptors whose meaning is more general than "RNA-Binding Protein EWS".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
RNA-Binding Protein EWS [D12.644.360.650]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Calmodulin-Binding Proteins [D12.776.157.142]
RNA-Binding Protein EWS [D12.776.157.142.750]
RNA-Binding Proteins [D12.776.157.725]
RNA Recognition Motif Proteins [D12.776.157.725.813]
Heterogeneous-Nuclear Ribonucleoproteins [D12.776.157.725.813.750]
RNA-Binding Protein EWS [D12.776.157.725.813.750.900]
Intracellular Signaling Peptides and Proteins [D12.776.476]
RNA-Binding Protein EWS [D12.776.476.650]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
RNA-Binding Protein EWS [D12.776.624.664.700.913]
Nucleoproteins [D12.776.664]
RNA-Binding Proteins [D12.776.664.962]
RNA Recognition Motif Proteins [D12.776.664.962.813]
Heterogeneous-Nuclear Ribonucleoproteins [D12.776.664.962.813.750]
RNA-Binding Protein EWS [D12.776.664.962.813.750.900]

Below are MeSH descriptors whose meaning is related to "RNA-Binding Protein EWS".

Below are MeSH descriptors whose meaning is more specific than "RNA-Binding Protein EWS".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "RNA-Binding Protein EWS" by people in this website by year, and whether "RNA-Binding Protein EWS" was a major or minor topic of these publications.

Bar chart showing 16 publications over 12 distinct years, with a maximum of 2 publications in 2012 and 2015 and 2019 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2010	0	1	1
2011	0	1	1
2012	0	2	2
2013	1	0	1
2014	0	1	1
2015	1	1	2
2017	1	0	1
2019	2	0	2
2020	0	1	1
2021	0	1	1
2024	1	1	2

Below are the most recent publications written about "RNA-Binding Protein EWS" by people in Profiles.

Lee JC, Koo SC, Furtado LV, Breuer A, Eldomery MK, Bag AK, Stow P, Rose G, Larkin T, Sances R, Kleinschmidt-DeMasters BK, Bodmer JL, Willard N, Gokden M, Dahiya S, Roberts K, Bertrand KC, Moreira DC, Robinson GW, Mo JQ, Ellison DW, Orr BA. Concurrent ependymal and ganglionic differentiation in a subset of supratentorial neuroepithelial tumors with EWSR1-PLAGL1 rearrangement. Acta Neuropathol Commun. 2024 09 03; 12(1):143.

View in: PubMed
Christensen D, Belair JA, BasuMallick A, Brown SA, Klein M, Jiang W. Synchronous Low-Grade Central Osteosarcoma and Ewing Sarcoma: A Rare Case Report. Int J Surg Pathol. 2025 Feb; 33(1):131-137.

View in: PubMed
Righi A, Pacheco M, Pipola V, Gambarotti M, Benini S, Sbaraglia M, Frisoni T, Boriani S, Dei Tos AP, Gasbarrini A. Primary sclerosing epithelioid fibrosarcoma of the spine: a single-institution experience. Histopathology. 2021 Jun; 78(7):976-986.

View in: PubMed
Theisen ER, Selich-Anderson J, Miller KR, Tanner JM, Taslim C, Pishas KI, Sharma S, Lessnick SL. Chromatin profiling reveals relocalization of lysine-specific demethylase 1 by an oncogenic fusion protein. Epigenetics. 2021 04; 16(4):405-424.

View in: PubMed
Benini S, Gamberi G, Cocchi S, Righi A, Frisoni T, Longhi A, Gambarotti M. Identification of a novel fusion transcript EWSR1-VEZF1 by anchored multiplex PCR in malignant peripheral nerve sheath tumor. Pathol Res Pract. 2020 Jan; 216(1):152760.

View in: PubMed
Pei J, Zhao X, Patchefsky AS, Flieder DB, Talarchek JN, Testa JR, Wei S. Clinical application of RNA sequencing in sarcoma diagnosis: An institutional experience. Medicine (Baltimore). 2019 Jun; 98(25):e16031.

View in: PubMed
Finos L, Righi A, Frisoni T, Gambarotti M, Ghinelli C, Benini S, Vanel D, Picci P. Primary extraskeletal myxoid chondrosarcoma of bone: Report of three cases and review of the literature. Pathol Res Pract. 2017 May; 213(5):461-466.

View in: PubMed
Klufas MA, Wolden SL, Bohle GC, Wexler LH, Abramson DH. Exenteration and Custom Implant Brachytherapy as a Treatment for Recurrent Primary Extraskeletal Orbital Ewing Sarcoma. Ophthalmic Plast Reconstr Surg. 2015 Jul-Aug; 31(4):e89-91.

View in: PubMed
Selvanathan SP, Graham GT, Erkizan HV, Dirksen U, Natarajan TG, Dakic A, Yu S, Liu X, Paulsen MT, Ljungman ME, Wu CH, Lawlor ER, ?ren A, Toretsky JA. Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):E1307-16.

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Benini S, Cocchi S, Gamberi G, Magagnoli G, Vogel D, Ghinelli C, Righi A, Picci P, Alberghini M, Gambarotti M. Diagnostic utility of molecular investigation in extraskeletal myxoid chondrosarcoma. J Mol Diagn. 2014 May; 16(3):314-23.

View in: PubMed

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