Cyclin-Dependent Kinase Inhibitor Proteins

"Cyclin-Dependent Kinase Inhibitor Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A group of cell cycle proteins that negatively regulate the activity of CYCLIN/CYCLIN-DEPENDENT KINASE complexes. They inhibit CELL CYCLE progression and help control CELL PROLIFERATION following GENOTOXIC STRESS as well as during CELL DIFFERENTIATION.

Descriptor ID	D050756
MeSH Number(s)	D12.644.360.225 D12.776.167.187 D12.776.476.225 D12.776.624.776.355
Concept/Terms	Cyclin-Dependent Kinase Inhibitor Proteins Cyclin-Dependent Kinase Inhibitor Proteins Cyclin Dependent Kinase Inhibitor Proteins CKI Proteins CDKI Proteins Cyclin-Kinase Inhibitor Proteins Cyclin Kinase Inhibitor Proteins Inhibitor Proteins, Cyclin-Kinase CIP-KIP Cyclin-Dependent Kinase Inhibitors CIP-KIP Cyclin-Dependent Kinase Inhibitors CIP KIP Cyclin Dependent Kinase Inhibitors CIP-KIP CKI Proteins CIP KIP CKI Proteins CKI Proteins, CIP-KIP CIP-KIP CDKI Proteins CDKI Proteins, CIP-KIP CIP KIP CDKI Proteins INK4 Cyclin-Dependent Kinase Inhibitors INK4 Cyclin-Dependent Kinase Inhibitors INK4 Cyclin Dependent Kinase Inhibitors INK4 CDKI Proteins CDKI Proteins, INK4 INK4 CKI Proteins CKI Proteins, INK4 Inhibitors of Cyclin-Dependent Kinase 4 Proteins Inhibitors of Cyclin Dependent Kinase 4 Proteins

Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase Inhibitor Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.644.360.225]
Proteins [D12.776]
Cell Cycle Proteins [D12.776.167]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.167.187]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.476.225]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.624.776.355]

Below are MeSH descriptors whose meaning is related to "Cyclin-Dependent Kinase Inhibitor Proteins".

Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase Inhibitor Proteins".

Cyclin-Dependent Kinase Inhibitor Proteins
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor p18
Cyclin-Dependent Kinase Inhibitor p19
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinase Inhibitor p57

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclin-Dependent Kinase Inhibitor Proteins" by people in this website by year, and whether "Cyclin-Dependent Kinase Inhibitor Proteins" was a major or minor topic of these publications.

Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 2003 and 2006 and 2008 and 2009 and 2012 and 2014 and 2023

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2006	0	1	1
2008	0	1	1
2009	0	1	1
2012	1	0	1
2014	0	1	1
2023	0	1	1

Below are the most recent publications written about "Cyclin-Dependent Kinase Inhibitor Proteins" by people in Profiles.

Tillmanns N, Lost J, Tabor J, Vasandani S, Vetsa S, Marianayagam N, Yalcin K, Erson-Omay EZ, von Reppert M, Jekel L, Merkaj S, Ramakrishnan D, Avesta A, de Oliveira Santo ID, Jin L, Huttner A, Bousabarah K, Ikuta I, Lin M, Aneja S, Turowski B, Aboian M, Moliterno J. Application of novel PACS-based informatics platform to identify imaging based predictors of CDKN2A allelic status in glioblastomas. Sci Rep. 2023 12 22; 13(1):22942.

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Casimiro MC, Velasco-Vel?zquez M, Aguirre-Alvarado C, Pestell RG. Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: past and present. Expert Opin Investig Drugs. 2014 Mar; 23(3):295-304.

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Capparelli C, Chiavarina B, Whitaker-Menezes D, Pestell TG, Pestell RG, Hulit J, And? S, Howell A, Martinez-Outschoorn UE, Sotgia F, Lisanti MP. CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Cell Cycle. 2012 Oct 01; 11(19):3599-610.

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Velasco-Vel?zquez MA, Yu Z, Jiao X, Pestell RG. Cancer stem cells and the cell cycle: targeting the drive behind breast cancer. Expert Rev Anticancer Ther. 2009 Mar; 9(3):275-9.

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G?ller M, Toualbi-Abed K, Legrand A, Michel L, Mauviel A, Bernuau D, Daniel F. c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1. World J Gastroenterol. 2008 Nov 07; 14(41):6339-46.

View in: PubMed
Bouzahzah B, Nagajyothi F, Desruisseaux MS, Krishnamachary M, Factor SM, Cohen AW, Lisanti MP, Petkova SB, Pestell RG, Wittner M, Mukherjee S, Weiss LM, Jelicks LA, Albanese C, Tanowitz HB. Cell cycle regulatory proteins in the liver in murine Trypanosoma cruzi infection. Cell Cycle. 2006 Oct; 5(20):2396-400.

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Schindler K, Benjamin KR, Martin A, Boglioli A, Herskowitz I, Winter E. The Cdk-activating kinase Cak1p promotes meiotic S phase through Ime2p. Mol Cell Biol. 2003 Dec; 23(23):8718-28.

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