Myeloid-Lymphoid Leukemia Protein

"Myeloid-Lymphoid Leukemia Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Myeloid-lymphoid leukemia protein is a transcription factor that maintains high levels of HOMEOTIC GENE expression during development. The GENE for myeloid-lymphoid leukemia protein is commonly disrupted in LEUKEMIA and combines with over 40 partner genes to form FUSION ONCOGENE PROTEINS.

Descriptor ID	D051788
MeSH Number(s)	D12.776.260.560 D12.776.624.664.700.148 D12.776.930.483
Concept/Terms	Myeloid-Lymphoid Leukemia Protein Myeloid-Lymphoid Leukemia Protein Myeloid Lymphoid Leukemia Protein Zinc Finger Protein HRX MLL Proto-Oncogene Protein MLL Proto Oncogene Protein Proto-Oncogene Protein, MLL Proto-Oncogene Proteins MLL MLL, Proto-Oncogene Proteins Proto Oncogene Proteins MLL Acute Lymphoblastic Leukemia Protein 1 Mixed-Lineage Leukemia Protein Mixed Lineage Leukemia Protein

Below are MeSH descriptors whose meaning is more general than "Myeloid-Lymphoid Leukemia Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Myeloid-Lymphoid Leukemia Protein [D12.776.260.560]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
Myeloid-Lymphoid Leukemia Protein [D12.776.624.664.700.148]
Transcription Factors [D12.776.930]
Myeloid-Lymphoid Leukemia Protein [D12.776.930.483]

Below are MeSH descriptors whose meaning is related to "Myeloid-Lymphoid Leukemia Protein".

Below are MeSH descriptors whose meaning is more specific than "Myeloid-Lymphoid Leukemia Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Myeloid-Lymphoid Leukemia Protein" by people in this website by year, and whether "Myeloid-Lymphoid Leukemia Protein" was a major or minor topic of these publications.

Bar chart showing 13 publications over 9 distinct years, with a maximum of 2 publications in 2003 and 2008 and 2010 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	0	2	2
2008	2	0	2
2010	2	0	2
2011	1	0	1
2012	1	0	1
2015	1	0	1
2020	1	0	1
2022	1	1	2

Below are the most recent publications written about "Myeloid-Lymphoid Leukemia Protein" by people in Profiles.

Gracia-Maldonado G, Clark J, Burwinkel M, Greenslade B, Wunderlich M, Salomonis N, Leone D, Gatti E, Pierre P, Kumar AR, Lee LH. LAMP-5 is an essential inflammatory-signaling regulator and novel immunotherapy target for mixed lineage leukemia-rearranged acute leukemia. Haematologica. 2022 04 01; 107(4):803-815.

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Heikamp EB, Henrich JA, Perner F, Wong EM, Hatton C, Wen Y, Barwe SP, Gopalakrishnapillai A, Xu H, Uckelmann HJ, Takao S, Kazansky Y, Pikman Y, McGeehan GM, Kolb EA, Kentsis A, Armstrong SA. The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML. Blood. 2022 02 10; 139(6):894-906.

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Itskovich SS, Gurunathan A, Clark J, Burwinkel M, Wunderlich M, Berger MR, Kulkarni A, Chetal K, Venkatasubramanian M, Salomonis N, Kumar AR, Lee LH. MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia. Nat Commun. 2020 05 12; 11(1):2369.

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Roychoudhury J, Clark JP, Gracia-Maldonado G, Unnisa Z, Wunderlich M, Link KA, Dasgupta N, Aronow B, Huang G, Mulloy JC, Kumar AR. MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia. Blood. 2015 Apr 16; 125(16):2544-52.

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Bindels EM, Havermans M, Lugthart S, Erpelinck C, Wocjtowicz E, Krivtsov AV, Rombouts E, Armstrong SA, Taskesen E, Haanstra JR, Beverloo HB, D?hner H, Hudson WA, Kersey JH, Delwel R, Kumar AR. EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs. Blood. 2012 Jun 14; 119(24):5838-49.

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Kumar AR, Yao Q, Li Q, Sam TA, Kersey JH. Authors' comments: t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL. Leuk Res. 2011 May; 35(5):697.

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Kumar AR, Yao Q, Li Q, Sam TA, Kersey JH. t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL. Leuk Res. 2011 Mar; 35(3):305-9.

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Kumar AR, Sarver AL, Wu B, Kersey JH. Meis1 maintains stemness signature in MLL-AF9 leukemia. Blood. 2010 Apr 29; 115(17):3642-3.

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Kumar AR, Li Q, Hudson WA, Chen W, Sam T, Yao Q, Lund EA, Wu B, Kowal BJ, Kersey JH. A role for MEIS1 in MLL-fusion gene leukemia. Blood. 2009 Feb 19; 113(8):1756-8.

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Chen W, Kumar AR, Hudson WA, Li Q, Wu B, Staggs RA, Lund EA, Sam TN, Kersey JH. Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells. Cancer Cell. 2008 May; 13(5):432-40.

View in: PubMed

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