Myristoylated Alanine-Rich C Kinase Substrate
"Myristoylated Alanine-Rich C Kinase Substrate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A membrane and ACTIN CYTOSKELETON associated, N-terminal myristoylated protein that binds CALMODULIN and is a prominent substrate for PROTEIN KINASE C. Both phosphorylation and poly(ADP)-ribosylation inhibit its F-ACTIN crosslinking activity; phosphorylation also causes MARCKS to relocate from the membrane to cytoplasm.
| Descriptor ID |
D000076250
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| MeSH Number(s) |
D05.750.078.730.556 D12.644.360.537 D12.776.157.142.375 D12.776.157.687.496 D12.776.220.525.556 D12.776.476.539 D12.776.543.637 D12.776.660.720.496
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Myristoylated Alanine-Rich C Kinase Substrate".
Below are MeSH descriptors whose meaning is more specific than "Myristoylated Alanine-Rich C Kinase Substrate".
This graph shows the total number of publications written about "Myristoylated Alanine-Rich C Kinase Substrate" by people in this website by year, and whether "Myristoylated Alanine-Rich C Kinase Substrate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Myristoylated Alanine-Rich C Kinase Substrate" by people in Profiles.
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Manai M, ELBini-Dhouib I, Finetti P, Bichiou H, Reduzzi C, Aissaoui D, Ben-Hamida N, Agavnian E, Srairi-Abid N, Lopez M, Amri F, Guizani-Tabbane L, Rahal K, Mrad K, Manai M, Birnbaum D, Mamessier E, Cristofanilli M, Boussen H, Kharrat M, Doghri R, Bertucci F. MARCKS as a Potential Therapeutic Target in Inflammatory Breast Cancer. Cells. 2022 09 19; 11(18).
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Seykora JT, Myat MM, Allen LA, Ravetch JV, Aderem A. Molecular determinants of the myristoyl-electrostatic switch of MARCKS. J Biol Chem. 1996 Aug 02; 271(31):18797-802.
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Seykora JT, Ravetch JV, Aderem A. Cloning and molecular characterization of the murine macrophage "68-kDa" protein kinase C substrate and its regulation by bacterial lipopolysaccharide. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2505-9.