Ribosomal Protein S6 Kinases

"Ribosomal Protein S6 Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.

Descriptor ID	D019893
MeSH Number(s)	D08.811.913.696.620.682.700.862 D12.644.360.600 D12.776.476.600
Concept/Terms	Ribosomal Protein S6 Kinases Ribosomal Protein S6 Kinases S6-H4 Kinase S6 H4 Kinase Ribosomal Protein S6 Kinase S6 Kinase

Below are MeSH descriptors whose meaning is more general than "Ribosomal Protein S6 Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Ribosomal Protein S6 Kinases [D08.811.913.696.620.682.700.862]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Ribosomal Protein S6 Kinases [D12.644.360.600]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Ribosomal Protein S6 Kinases [D12.776.476.600]

Below are MeSH descriptors whose meaning is related to "Ribosomal Protein S6 Kinases".

Below are MeSH descriptors whose meaning is more specific than "Ribosomal Protein S6 Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ribosomal Protein S6 Kinases" by people in this website by year, and whether "Ribosomal Protein S6 Kinases" was a major or minor topic of these publications.

Bar chart showing 8 publications over 7 distinct years, with a maximum of 2 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	1	0	1
2001	0	1	1
2002	0	2	2
2006	1	0	1
2014	0	1	1
2016	0	1	1

Below are the most recent publications written about "Ribosomal Protein S6 Kinases" by people in Profiles.

Yarchoan M, Ma C, Troxel AB, Stopenski SJ, Tang W, Cohen AB, Pappas-Paxinos M, Johnson BA, Chen EY, Feldman MD, Brose MS. pAKT Expression and Response to Sorafenib in Differentiated Thyroid Cancer. Horm Cancer. 2016 06; 7(3):188-95.

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Silver L, Michael JV, Goldfinger LE, Gallo G. Activation of PI3K and R-Ras signaling promotes the extension of sensory axons on inhibitory chondroitin sulfate proteoglycans. Dev Neurobiol. 2014 Sep; 74(9):918-33.

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Han S, Khuri FR, Roman J. Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways. Cancer Res. 2006 Jan 01; 66(1):315-23.

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Belletti B, Drakas R, Morrione A, Tu X, Prisco M, Yuan T, Casaburi I, Baserga R. Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor. Exp Cell Res. 2002 Jul 1; 277(1):107-18.

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Andreoni KA, Wang X, Huang SM, Huang ES. Human cytomegalovirus hyperimmune globulin not only neutralizes HCMV infectivity, but also inhibits HCMV-induced intracellular NF-kappaB, Sp1, and PI3-K signaling pathways. J Med Virol. 2002 May; 67(1):33-40.

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Morrione A, Navarro M, Romano G, Dews M, Reiss K, Valentinis B, Belletti B, Baserga R. The role of the insulin receptor substrate-1 in the differentiation of rat hippocampal neuronal cells. Oncogene. 2001 Aug 09; 20(35):4842-52.

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Valentinis B, Navarro M, Zanocco-Marani T, Edmonds P, McCormick J, Morrione A, Sacchi A, Romano G, Reiss K, Baserga R. Insulin receptor substrate-1, p70S6K, and cell size in transformation and differentiation of hemopoietic cells. J Biol Chem. 2000 Aug 18; 275(33):25451-9.

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Krymskaya VP, Penn RB, Orsini MJ, Scott PH, Plevin RJ, Walker TR, Eszterhas AJ, Amrani Y, Chilvers ER, Panettieri RA. Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation. Am J Physiol. 1999 07; 277(1):L65-78.

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