I-kappa B Kinase

"I-kappa B Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.

Descriptor ID	D051550
MeSH Number(s)	D08.811.913.696.620.682.700.494 D12.644.360.361 D12.776.476.378
Concept/Terms	I-kappa B Kinase I-kappa B Kinase B Kinase, I-kappa Kinase, I-kappa B NK-kappa B-Activating Kinase NAK NK kappa B Activating Kinase NAK IkappaB Kinase Kinase, IkappaB I kappa B Kinase IkappaB Kinase gamma IkappaB Kinase gamma IKK gamma NF-kappaB Essential Modifier Essential Modifier, NF-kappaB NF kappaB Essential Modifier IkappaB Kinase epsilon IkappaB Kinase epsilon Kinase epsilon, IkappaB IKK epsilon IKKepsilon IkappaB Kinase alpha IkappaB Kinase alpha Kinase alpha, IkappaB IKK 1 Kinase IKK alpha Conserved Helix-Loop-Helix Ubiquitous Kinase Conserved Helix Loop Helix Ubiquitous Kinase CHUK Kinase I Kappa B alpha-Associated Protein Kinase I Kappa B alpha Associated Protein Kinase IkappaBalpha Kinase IkappaB Kinase beta IkappaB Kinase beta Kinase beta, IkappaB IKK beta IKBKB IKK 2 Kinase

Below are MeSH descriptors whose meaning is more general than "I-kappa B Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
I-kappa B Kinase [D08.811.913.696.620.682.700.494]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
I-kappa B Kinase [D12.644.360.361]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
I-kappa B Kinase [D12.776.476.378]

Below are MeSH descriptors whose meaning is related to "I-kappa B Kinase".

Below are MeSH descriptors whose meaning is more specific than "I-kappa B Kinase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "I-kappa B Kinase" by people in this website by year, and whether "I-kappa B Kinase" was a major or minor topic of these publications.

Bar chart showing 11 publications over 9 distinct years, with a maximum of 2 publications in 2006 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	0	1	1
2006	0	2	2
2007	0	1	1
2010	0	1	1
2011	0	1	1
2014	0	1	1
2016	2	0	2
2018	0	1	1

Below are the most recent publications written about "I-kappa B Kinase" by people in Profiles.

Caracciolo V, Young J, Gonzales D, Ni Y, Flowers SJ, Summer R, Waldman SA, Kim JK, Jung DY, Noh HL, Kim T, Blackshear PJ, O'Connell D, Bauer RC, Kallen CB. Myeloid-specific deletion of Zfp36 protects against insulin resistance and fatty liver in diet-induced obese mice. Am J Physiol Endocrinol Metab. 2018 10 01; 315(4):E676-E693.

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Rashidghamat E, Hsu CK, Nanda A, Liu L, Al-Ajmi H, McGrath JA. Incontinentia pigmenti in a father and daughter. Br J Dermatol. 2016 Nov; 175(5):1059-1060.

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T?treault MP, Weinblatt D, Ciolino JD, Klein-Szanto AJ, Sackey BK, Twyman-Saint Victor C, Karakasheva T, Teal V, Katz JP. Esophageal Expression of Active I?B Kinase-? in Mice?Up-Regulates Tumor Necrosis Factor and Granulocyte-Macrophage Colony-Stimulating Factor, Promoting?Inflammation and Angiogenesis. Gastroenterology. 2016 06; 150(7):1609-1619.e11.

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Wesolowski J, Paumet F. Escherichia coli exposure inhibits exocytic SNARE-mediated membrane fusion in mast cells. Traffic. 2014 May; 15(5):516-30.

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Ikeda F, Deribe YL, Sk?nland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I. SHARPIN forms a linear ubiquitin ligase complex regulating NF-?B activity and apoptosis. Nature. 2011 Mar 31; 471(7340):637-41.

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Alvarez-Guardia D, Palomer X, Coll T, Davidson MM, Chan TO, Feldman AM, Laguna JC, V?zquez-Carrera M. The p65 subunit of NF-kappaB binds to PGC-1alpha, linking inflammation and metabolic disturbances in cardiac cells. Cardiovasc Res. 2010 Aug 01; 87(3):449-58.

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O'Neil BH, Buzkov? P, Farrah H, Kashatus D, Sanoff H, Goldberg RM, Baldwin AS, Funkhouser WK. Expression of nuclear factor-kappaB family proteins in hepatocellular carcinomas. Oncology. 2007; 72(1-2):97-104.

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Parameswaran N, Pao CS, Leonhard KS, Kang DS, Kratz M, Ley SC, Benovic JL. Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages. J Biol Chem. 2006 Nov 10; 281(45):34159-70.

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Narayan P, Holt B, Tosti R, Kane LP. CARMA1 is required for Akt-mediated NF-kappaB activation in T cells. Mol Cell Biol. 2006 Mar; 26(6):2327-36.

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Raychaudhuri B, Abraham S, Bonfield TL, Malur A, Deb A, DiDonato JA, Kavuru MS, Thomassen MJ. Surfactant blocks lipopolysaccharide signaling by inhibiting both mitogen-activated protein and IkappaB kinases in human alveolar macrophages. Am J Respir Cell Mol Biol. 2004 Feb; 30(2):228-32.

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