G-Protein-Coupled Receptor Kinases

"G-Protein-Coupled Receptor Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of serine-threonine kinases that are specific for G-PROTEIN-COUPLED RECEPTORS. They are regulatory proteins that play a role in G-protein-coupled receptor densensitization.

Descriptor ID	D054768
MeSH Number(s)	D08.811.913.696.620.682.700.364 D12.644.360.293 D12.776.476.293
Concept/Terms	G-Protein-Coupled Receptor Kinases G-Protein-Coupled Receptor Kinases G Protein Coupled Receptor Kinases Kinases, G-Protein-Coupled Receptor Receptor Kinases, G-Protein-Coupled

Below are MeSH descriptors whose meaning is more general than "G-Protein-Coupled Receptor Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
G-Protein-Coupled Receptor Kinases [D08.811.913.696.620.682.700.364]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
G-Protein-Coupled Receptor Kinases [D12.644.360.293]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
G-Protein-Coupled Receptor Kinases [D12.776.476.293]

Below are MeSH descriptors whose meaning is related to "G-Protein-Coupled Receptor Kinases".

Below are MeSH descriptors whose meaning is more specific than "G-Protein-Coupled Receptor Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "G-Protein-Coupled Receptor Kinases" by people in this website by year, and whether "G-Protein-Coupled Receptor Kinases" was a major or minor topic of these publications.

Bar chart showing 33 publications over 20 distinct years, with a maximum of 4 publications in 1997 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	2	2
1997	0	4	4
1999	0	1	1
2000	0	2	2
2003	0	1	1
2005	0	2	2
2006	0	2	2
2007	1	1	2
2008	2	0	2
2009	1	0	1
2010	0	1	1
2011	3	1	4
2012	1	0	1
2016	1	0	1
2017	2	0	2
2019	0	1	1
2020	1	0	1
2021	1	0	1
2022	1	0	1
2024	0	1	1

Below are the most recent publications written about "G-Protein-Coupled Receptor Kinases" by people in Profiles.

Varney MJ, Benovic JL. The Role of G Protein-Coupled Receptors and Receptor Kinases in Pancreatic ?-Cell Function and Diabetes. Pharmacol Rev. 2024 Feb 13; 76(2):267-299.

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Varney MJ, Steyaert W, Coucke PJ, Delanghe JR, Uehling DE, Joseph B, Marcellus R, Al-Awar R, Benovic JL. G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin. J Biol Chem. 2022 10; 298(10):102421.

View in: PubMed
Benovic JL. Historical Perspective of the G Protein-Coupled Receptor Kinase Family. Cells. 2021 03 04; 10(3).

View in: PubMed
Chen X, Zhao X, Cooper M, Ma P. The Roles of GRKs in Hemostasis and Thrombosis. Int J Mol Sci. 2020 Jul 28; 21(15).

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Lagman J, Sayegh P, Lee CS, Sulon SM, Jacinto AZ, Sok V, Peng N, Alp D, Benovic JL, So CH. G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel. Mol Cell Biochem. 2019 Nov; 461(1-2):103-118.

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Komolov KE, Benovic JL. G protein-coupled receptor kinases: Past, present and future. Cell Signal. 2018 01; 41:17-24.

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Wang J, Luo J, Aryal DK, Wetsel WC, Nass R, Benovic JL. G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans. J Biol Chem. 2017 04 07; 292(14):5943-5956.

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DeRita RM, Zerlanko B, Singh A, Lu H, Iozzo RV, Benovic JL, Languino LR. c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes. J Cell Biochem. 2017 01; 118(1):66-73.

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Wood JF, Wang J, Benovic JL, Ferkey DM. Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo. J Biol Chem. 2012 Apr 13; 287(16):12634-44.

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Bychkov ER, Ahmed MR, Gurevich VV, Benovic JL, Gurevich EV. Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder. Neurobiol Dis. 2011 Nov; 44(2):248-58.

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