G-Protein-Coupled Receptor Kinases

"G-Protein-Coupled Receptor Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of serine-threonine kinases that are specific for G-PROTEIN-COUPLED RECEPTORS. They are regulatory proteins that play a role in G-protein-coupled receptor densensitization.

Descriptor ID	D054768
MeSH Number(s)	D08.811.913.696.620.682.700.364 D12.644.360.293 D12.776.476.293
Concept/Terms	G-Protein-Coupled Receptor Kinases G-Protein-Coupled Receptor Kinases G Protein Coupled Receptor Kinases Kinases, G-Protein-Coupled Receptor Receptor Kinases, G-Protein-Coupled

Below are MeSH descriptors whose meaning is more general than "G-Protein-Coupled Receptor Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
G-Protein-Coupled Receptor Kinases [D08.811.913.696.620.682.700.364]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
G-Protein-Coupled Receptor Kinases [D12.644.360.293]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
G-Protein-Coupled Receptor Kinases [D12.776.476.293]

Below are MeSH descriptors whose meaning is related to "G-Protein-Coupled Receptor Kinases".

Below are MeSH descriptors whose meaning is more specific than "G-Protein-Coupled Receptor Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "G-Protein-Coupled Receptor Kinases" by people in this website by year, and whether "G-Protein-Coupled Receptor Kinases" was a major or minor topic of these publications.

Bar chart showing 29 publications over 17 distinct years, with a maximum of 4 publications in 1997 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	2	2
1997	0	4	4
1999	0	1	1
2000	0	2	2
2003	0	1	1
2005	0	2	2
2006	0	2	2
2007	1	1	2
2008	2	0	2
2009	1	0	1
2010	0	1	1
2011	3	1	4
2012	1	0	1
2017	1	0	1
2020	1	0	1
2022	1	0	1
2024	0	1	1

Below are the most recent publications written about "G-Protein-Coupled Receptor Kinases" by people in Profiles.

Varney MJ, Benovic JL. The Role of G Protein-Coupled Receptors and Receptor Kinases in Pancreatic ?-Cell Function and Diabetes. Pharmacol Rev. 2024 Feb 13; 76(2):267-299.

View in: PubMed
Varney MJ, Steyaert W, Coucke PJ, Delanghe JR, Uehling DE, Joseph B, Marcellus R, Al-Awar R, Benovic JL. G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin. J Biol Chem. 2022 10; 298(10):102421.

View in: PubMed
Chen X, Zhao X, Cooper M, Ma P. The Roles of GRKs in Hemostasis and Thrombosis. Int J Mol Sci. 2020 Jul 28; 21(15).

View in: PubMed
Wang J, Luo J, Aryal DK, Wetsel WC, Nass R, Benovic JL. G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans. J Biol Chem. 2017 Apr 07; 292(14):5943-5956.

View in: PubMed
Wood JF, Wang J, Benovic JL, Ferkey DM. Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo. J Biol Chem. 2012 Apr 13; 287(16):12634-44.

View in: PubMed
Bychkov ER, Ahmed MR, Gurevich VV, Benovic JL, Gurevich EV. Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder. Neurobiol Dis. 2011 Nov; 44(2):248-58.

View in: PubMed
Robinett KS, Deshpande DA, Malone MM, Liggett SB. Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors. Am J Respir Cell Mol Biol. 2011 Nov; 45(5):1069-74.

View in: PubMed
Huang ZM, Gold JI, Koch WJ. G protein-coupled receptor kinases in normal and failing myocardium. Front Biosci (Landmark Ed). 2011 06 01; 16(8):3047-60.

View in: PubMed
Raake PW, Koch WJ, Most P. Polymorphisms present in G-protein-coupled receptor kinases and their effect on ?-blocker treatment. Pharmacogenomics. 2011 Mar; 12(3):295-7.

View in: PubMed
Busillo JM, Armando S, Sengupta R, Meucci O, Bouvier M, Benovic JL. Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J Biol Chem. 2010 Mar 5; 285(10):7805-17.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement