Ataxia Telangiectasia Mutated Proteins

"Ataxia Telangiectasia Mutated Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A group of PROTEIN-SERINE-THREONINE KINASES which activate critical signaling cascades in double strand breaks, APOPTOSIS, and GENOTOXIC STRESS such as ionizing ultraviolet A light, thereby acting as a DNA damage sensor. These proteins play a role in a wide range of signaling mechanisms in cell cycle control.

Descriptor ID	D064007
MeSH Number(s)	D08.811.913.696.620.682.700.097 D12.776.157.687.125 D12.776.660.720.125
Concept/Terms	Ataxia Telangiectasia Mutated Proteins Ataxia Telangiectasia Mutated Proteins AT Mutated Protein Mutated Protein, AT Protein, AT Mutated ATM Protein A-T Protein A T Protein Protein, A-T

Below are MeSH descriptors whose meaning is more general than "Ataxia Telangiectasia Mutated Proteins".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Ataxia Telangiectasia Mutated Proteins [D08.811.913.696.620.682.700.097]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Poly-ADP-Ribose Binding Proteins [D12.776.157.687]
Ataxia Telangiectasia Mutated Proteins [D12.776.157.687.125]
Nuclear Proteins [D12.776.660]
Poly-ADP-Ribose Binding Proteins [D12.776.660.720]
Ataxia Telangiectasia Mutated Proteins [D12.776.660.720.125]

Below are MeSH descriptors whose meaning is related to "Ataxia Telangiectasia Mutated Proteins".

Below are MeSH descriptors whose meaning is more specific than "Ataxia Telangiectasia Mutated Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ataxia Telangiectasia Mutated Proteins" by people in this website by year, and whether "Ataxia Telangiectasia Mutated Proteins" was a major or minor topic of these publications.

Bar chart showing 28 publications over 16 distinct years, with a maximum of 5 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	3	3
2003	0	1	1
2004	0	2	2
2005	0	2	2
2007	0	1	1
2008	0	1	1
2009	0	1	1
2010	0	2	2
2011	0	1	1
2012	0	1	1
2014	0	1	1
2015	0	1	1
2019	2	1	3
2021	4	1	5
2022	0	2	2
2023	0	1	1

Below are the most recent publications written about "Ataxia Telangiectasia Mutated Proteins" by people in Profiles.

Luo D, Mladenov E, Soni A, Stuschke M, Iliakis G. The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G2-Checkpoint Activation in Cells Exposed to Ionizing Radiation. Cells. 2023 05 14; 12(10).

View in: PubMed
Madgwick S, Luli S, Sellier H, Butterworth JA, Leslie J, Moore AJ, Corbin EK, Yemm AI, Chiremba RT, Tiniakos D, Oakley F, Perkins ND, Hunter JE. Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential. Biochem J. 2022 10 14; 479(19):2115-2130.

View in: PubMed
Soni A, Duan X, Stuschke M, Iliakis G. ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions. Int J Mol Sci. 2022 Jul 06; 23(14).

View in: PubMed
Li F, Mladenov E, Dueva R, Stuschke M, Timmermann B, Iliakis G. Shift in G1-Checkpoint from ATM-Alone to a Cooperative ATM Plus ATR Regulation with Increasing Dose of Radiation. Cells. 2021 12 27; 11(1).

View in: PubMed
Krieger LM, Mladenov E, Soni A, Demond M, Stuschke M, Iliakis G. Disruption of Chromatin Dynamics by Hypotonic Stress Suppresses HR and Shifts DSB Processing to Error-Prone SSA. Int J Mol Sci. 2021 Oct 11; 22(20).

View in: PubMed
Torres MB, Diggs LP, Wei JS, Khan J, Miettinen M, Fasaye GA, Gillespie A, Widemann BC, Kaplan RN, Davis JL, Hernandez JM, Rivero JD. Ataxia telangiectasia mutated germline pathogenic variant in adrenocortical carcinoma. Cancer Genet. 2021 08; 256-257:21-25.

View in: PubMed
Soni A, Mladenov E, Iliakis G. Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses. DNA Repair (Amst). 2021 05; 101:103076.

View in: PubMed
McDuff SGR, Bellon JR, Shannon KM, Gadd MA, Dunn S, Rosenstein BS, Ho AY. ATM Variants in Breast Cancer: Implications for Breast Radiation Therapy Treatment Recommendations. Int J Radiat Oncol Biol Phys. 2021 08 01; 110(5):1373-1382.

View in: PubMed
Mladenov E, Fan X, Paul-Konietzko K, Soni A, Iliakis G. DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G2-checkpoint in S-phase irradiated cells. Sci Rep. 2019 10 10; 9(1):14597.

View in: PubMed
Mladenov E, Fan X, Dueva R, Soni A, Iliakis G. Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G2-phase. Sci Rep. 2019 06 04; 9(1):8255.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement