eIF-2 Kinase

"eIF-2 Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.

Descriptor ID	D019892
MeSH Number(s)	D08.811.913.696.620.682.700.300 D12.644.360.275 D12.776.476.275
Concept/Terms	eIF-2 Kinase eIF-2 Kinase Kinase, eIF-2 eIF 2 Kinase DAI Protein Kinase Kinase, DAI Protein Protein Kinase, DAI Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase Double Stranded RNA Dependent eIF 2 alpha Protein Kinase Double Stranded RNA-Dependent Kinase (dsl) dsRNA-Activated Inhibitor Inhibitor, dsRNA-Activated dsRNA Activated Inhibitor DSRNA-Dep Protein Kinase DSRNA Dep Protein Kinase Kinase, DSRNA-Dep Protein Protein Kinase, DSRNA-Dep eIF-2alpha Kinase Kinase, eIF-2alpha eIF 2alpha Kinase eRF, eIF-2 Recycling Factor eRF, eIF 2 Recycling Factor Eukaryotic Initiation Factor 2alpha Kinase Heme Controlled Repressor Controlled Repressor, Heme Repressor, Heme Controlled Heme-Controlled Inhibitor Heme Controlled Inhibitor Inhibitor, Heme-Controlled Heme-Regulated eIF-2alpha Kinase Heme Regulated eIF 2alpha Kinase Kinase, Heme-Regulated eIF-2alpha eIF-2alpha Kinase, Heme-Regulated Hemin Controlled Repressor Controlled Repressor, Hemin Repressor, Hemin Controlled p68 Kinase Kinase, p68 Self-Phosphorylating Protein Kinase Kinase, Self-Phosphorylating Protein Protein Kinase, Self-Phosphorylating Self Phosphorylating Protein Kinase TIK Kinase Kinase, TIK P68 Protein Kinase Kinase, P68 Protein Protein Kinase, P68 RNA-Dependent Protein Kinase Kinase, RNA-Dependent Protein Protein Kinase, RNA-Dependent RNA Dependent Protein Kinase p65 Kinase Kinase, p65 Protein Kinase PKR Kinase PKR, Protein PKR, Protein Kinase Protein Kinase, RNA Activated Heme-Controlled Translational Repressor Heme Controlled Translational Repressor Repressor, Heme-Controlled Translational Translational Repressor, Heme-Controlled Hemin-Controlled Translational Repressor Hemin Controlled Translational Repressor Repressor, Hemin-Controlled Translational Translational Repressor, Hemin-Controlled

Below are MeSH descriptors whose meaning is more general than "eIF-2 Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
eIF-2 Kinase [D08.811.913.696.620.682.700.300]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
eIF-2 Kinase [D12.644.360.275]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
eIF-2 Kinase [D12.776.476.275]

Below are MeSH descriptors whose meaning is related to "eIF-2 Kinase".

Below are MeSH descriptors whose meaning is more specific than "eIF-2 Kinase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "eIF-2 Kinase" by people in this website by year, and whether "eIF-2 Kinase" was a major or minor topic of these publications.

Bar chart showing 9 publications over 8 distinct years, with a maximum of 2 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2006	1	0	1
2007	0	1	1
2010	0	1	1
2013	0	1	1
2017	0	1	1
2019	1	0	1
2021	0	2	2

Below are the most recent publications written about "eIF-2 Kinase" by people in Profiles.

Gan L, Liu D, Xie D, Bond Lau W, Liu J, Christopher TA, Lopez B, Liu L, Hu H, Yao P, He Y, Gao E, Koch WJ, Zhao J, Ma XL, Cao Y, Wang Y. Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function. Circ Res. 2022 01 07; 130(1):48-66.

View in: PubMed
Li Y, Renner DM, Comar CE, Whelan JN, Reyes HM, Cardenas-Diaz FL, Truitt R, Tan LH, Dong B, Alysandratos KD, Huang J, Palmer JN, Adappa ND, Kohanski MA, Kotton DN, Silverman RH, Yang W, Morrisey EE, Cohen NA, Weiss SR. SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes. Proc Natl Acad Sci U S A. 2021 04 20; 118(16).

View in: PubMed
Piazzi M, Bavelloni A, Greco S, Focaccia E, Orsini A, Benini S, Gambarotti M, Faenza I, Blalock WL. Expression of the double-stranded RNA-dependent kinase PKR influences osteosarcoma attachment independent growth, migration, and invasion. J Cell Physiol. 2020 02; 235(2):1103-1119.

View in: PubMed
Gannon PJ, Akay-Espinoza C, Yee AC, Briand LA, Erickson MA, Gelman BB, Gao Y, Haughey NJ, Zink MC, Clements JE, Kim NS, Van De Walle G, Jensen BK, Vassar R, Pierce RC, Gill AJ, Kolson DL, Diehl JA, Mankowski JL, Jordan-Sciutto KL. HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via ß-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation. Am J Pathol. 2017 Jan; 187(1):91-109.

View in: PubMed
Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S. Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):E3109-18.

View in: PubMed
Blais JD, Chin KT, Zito E, Zhang Y, Heldman N, Harding HP, Fass D, Thorpe C, Ron D. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem. 2010 Jul 2; 285(27):20993-1003.

View in: PubMed
Nagata T, Ilieva H, Murakami T, Shiote M, Narai H, Ohta Y, Hayashi T, Shoji M, Abe K. Increased ER stress during motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis. Neurol Res. 2007 Dec; 29(8):767-71.

View in: PubMed
Smith KD, Mezhir JJ, Bickenbach K, Veerapong J, Charron J, Posner MC, Roizman B, Weichselbaum RR. Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1. J Virol. 2006 Feb; 80(3):1110-20.

View in: PubMed
Westwick JK, Lambert QT, Clark GJ, Symons M, Van Aelst L, Pestell RG, Der CJ. Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways. Mol Cell Biol. 1997 Mar; 17(3):1324-35.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement