Proto-Oncogene Proteins c-bcr
"Proto-Oncogene Proteins c-bcr" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.
| Descriptor ID |
D051562
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| MeSH Number(s) |
D08.811.913.696.620.682.700.759 D12.644.360.325.300.099.500 D12.776.476.325.300.099.500 D12.776.624.664.700.171
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| Concept/Terms |
Proto-Oncogene Proteins c-bcr- Proto-Oncogene Proteins c-bcr
- Proto Oncogene Proteins c bcr
- c-bcr, Proto-Oncogene Proteins
- Proto-Oncogene Protein c-bcr
- Proto Oncogene Protein c bcr
- c-bcr, Proto-Oncogene Protein
- Breakpoint Cluster Region Protein
- c-bcr Proteins
- c bcr Proteins
- c-bcr Proto-Oncogene Proteins
- Proto-Oncogene Proteins, c-bcr
- c bcr Proto Oncogene Proteins
- bcr Proto-Oncogene Proteins
- Proto-Oncogene Proteins, bcr
- bcr Proto Oncogene Proteins
- Proto-Oncogene Protein bcr
- Proto Oncogene Protein bcr
|
Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-bcr".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-bcr".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-bcr" by people in this website by year, and whether "Proto-Oncogene Proteins c-bcr" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-bcr" by people in Profiles.
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Kaileh M, Vazquez E, MacFarlane AW, Campbell K, Kurosaki T, Siebenlist U, Sen R. mTOR-Dependent and Independent Survival Signaling by PI3K in B Lymphocytes. PLoS One. 2016; 11(1):e0146955.
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Bartos JD, Gaile DP, McQuaid DE, Conroy JM, Darbary H, Nowak NJ, Block A, Petrelli NJ, Mittelman A, Stoler DL, Anderson GR. aCGH local copy number aberrations associated with overall copy number genomic instability in colorectal cancer: coordinate involvement of the regions including BCR and ABL. Mutat Res. 2007 Feb 03; 615(1-2):1-11.
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Safley AM, Sebastian S, Collins TS, Tirado CA, Stenzel TT, Gong JZ, Goodman BK. Molecular and cytogenetic characterization of a novel translocation t(4;22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia. Genes Chromosomes Cancer. 2004 May; 40(1):44-50.