rho-Associated Kinases

"rho-Associated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.

Descriptor ID	D054460
MeSH Number(s)	D08.811.913.696.620.682.700.814 D12.644.360.590 D12.776.476.595
Concept/Terms	rho-Associated Kinases rho-Associated Kinases rho Associated Kinases rho-Associated Kinase rho Associated Kinase ROCK Protein Kinases Protein Kinases, ROCK rho-Associated Coiled-Coil Kinase Coiled-Coil Kinase, rho-Associated rho Associated Coiled Coil Kinase rho-Kinase rho Kinase ROK Kinase rho-Associated Kinase 1 rho-Associated Kinase 1 rho Associated Kinase 1 ROCK-I Protein Kinase ROCK I Protein Kinase p160ROCK rho-Associated Kinase beta rho Associated Kinase beta rho-Associated Protein Kinase beta rho Associated Protein Kinase beta rho-Associated Coiled-Coil Containing Protein Kinase 1 rho Associated Coiled Coil Containing Protein Kinase 1 rho-Associated Kinase 2 rho-Associated Kinase 2 rho Associated Kinase 2 rho-Associated Kinase alpha rho Associated Kinase alpha rho-Associated Coiled-Coil Containing Protein Kinase 2 rho Associated Coiled Coil Containing Protein Kinase 2 ROCK-II Protein Kinase ROCK II Protein Kinase p160 rhoA-Binding Kinase ROKalpha p160 rhoA Binding Kinase ROKalpha rho-Associated Protein Kinase alpha rho Associated Protein Kinase alpha

Below are MeSH descriptors whose meaning is more general than "rho-Associated Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
rho-Associated Kinases [D08.811.913.696.620.682.700.814]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
rho-Associated Kinases [D12.644.360.590]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
rho-Associated Kinases [D12.776.476.595]

Below are MeSH descriptors whose meaning is related to "rho-Associated Kinases".

Below are MeSH descriptors whose meaning is more specific than "rho-Associated Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "rho-Associated Kinases" by people in this website by year, and whether "rho-Associated Kinases" was a major or minor topic of these publications.

Bar chart showing 39 publications over 14 distinct years, with a maximum of 5 publications in 2006 and 2007 and 2009 and 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	0	2	2
2004	0	1	1
2005	0	3	3
2006	0	5	5
2007	0	5	5
2008	3	1	4
2009	5	0	5
2010	1	0	1
2011	3	1	4
2012	2	3	5
2013	0	1	1
2014	0	1	1
2021	0	1	1

Below are the most recent publications written about "rho-Associated Kinases" by people in Profiles.

Singh A, Rattan S. BDNF rescues aging-associated internal anal sphincter dysfunction. Am J Physiol Gastrointest Liver Physiol. 2021 07 01; 321(1):G87-G97.

View in: PubMed
Yeganeh B, Wiechec E, Ande SR, Sharma P, Moghadam AR, Post M, Freed DH, Hashemi M, Shojaei S, Zeki AA, Ghavami S. Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease. Pharmacol Ther. 2014 Jul; 143(1):87-110.

View in: PubMed
Wilson AL, Schrecengost RS, Guerrero MS, Thomas KS, Bouton AH. Breast cancer antiestrogen resistance 3 (BCAR3) promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells. PLoS One. 2013; 8(6):e65678.

View in: PubMed
Wang QM, Stalker TJ, Gong Y, Rikitake Y, Scalia R, Liao JK. Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury. Vasc Med. 2012 Dec; 17(6):379-85.

View in: PubMed
Singh J, Rattan S. Bioengineered human IAS reconstructs with functional and molecular properties similar to intact IAS. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15; 303(6):G713-22.

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Khromov AS, Momotani K, Jin L, Artamonov MV, Shannon J, Eto M, Somlyo AV. Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle. J Biol Chem. 2012 Jun 15; 287(25):20975-85.

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Kim JI, Urban M, Young GD, Eto M. Reciprocal regulation controlling the expression of CPI-17, a specific inhibitor protein for the myosin light chain phosphatase in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2012 Jul 1; 303(1):C58-68.

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Rattan S, Singh J. RhoA/ROCK pathway is the major molecular determinant of basal tone in intact human internal anal sphincter. Am J Physiol Gastrointest Liver Physiol. 2012 Apr; 302(7):G664-75.

View in: PubMed
Singh J, Maxwell PJ, Rattan S. Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G317-25.

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Fehlings MG, Theodore N, Harrop J, Maurais G, Kuntz C, Shaffrey CI, Kwon BK, Chapman J, Yee A, Tighe A, McKerracher L. A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury. J Neurotrauma. 2011 May; 28(5):787-96.

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