Thyroid Nuclear Factor 1

"Thyroid Nuclear Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. It is critical for maintaining thyroid tissue in a differentiated state and also plays a role in lung development. Mutations in the NKX2-1 gene are associated with CHOREA, BENIGN HEREDITARY.

Descriptor ID	D000074482
MeSH Number(s)	D12.776.260.400.871 D12.776.660.823 D12.776.930.888
Concept/Terms	Thyroid Nuclear Factor 1 Thyroid Nuclear Factor 1 Thyroid Transcription Factor 1 TITF-1 Protein TITF 1 Protein Homeobox Protein Nkx-2.1 Homeobox Protein Nkx 2.1 Nkx-2.1, Homeobox Protein NK2 Homeobox 1 Protein TITF1 Protein TTF-1 Thyroid Nuclear Factor TTF 1 Thyroid Nuclear Factor Thyroid-Specific Enhancer-Binding Protein Enhancer-Binding Protein, Thyroid-Specific Thyroid Specific Enhancer Binding Protein

Below are MeSH descriptors whose meaning is more general than "Thyroid Nuclear Factor 1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Homeodomain Proteins [D12.776.260.400]
Thyroid Nuclear Factor 1 [D12.776.260.400.871]
Nuclear Proteins [D12.776.660]
Thyroid Nuclear Factor 1 [D12.776.660.823]
Transcription Factors [D12.776.930]
Thyroid Nuclear Factor 1 [D12.776.930.888]

Below are MeSH descriptors whose meaning is related to "Thyroid Nuclear Factor 1".

Below are MeSH descriptors whose meaning is more specific than "Thyroid Nuclear Factor 1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Thyroid Nuclear Factor 1" by people in this website by year, and whether "Thyroid Nuclear Factor 1" was a major or minor topic of these publications.

Bar chart showing 8 publications over 7 distinct years, with a maximum of 2 publications in 2000

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	2	2
2002	0	1	1
2004	0	1	1
2006	0	1	1
2018	0	1	1
2019	0	1	1
2024	1	0	1

Below are the most recent publications written about "Thyroid Nuclear Factor 1" by people in Profiles.

Das S, Ahlawat S, Sarangi J, Panda AK, Jain P, Gupta RK, Vaishya S, Patir R. TTF-1 immunohistochemistry in primary CNS tumors: A systematic review. Clin Neuropathol. 2024 Sept./Oct. & Nov./Dec.; 43(5 & 6):138-146.

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Roberts EA, Morrison LE, Behman LJ, Draganova-Tacheva R, O'Neill R, Solomides CC. Chromogenic immunohistochemical quadruplex provides accurate diagnostic differentiation of non-small cell lung cancer. Ann Diagn Pathol. 2020 Apr; 45:151454.

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Gupta RK, Batra VV, Singh D, Sharma MC, Kumar V. Is spindle cell oncocytoma a true entity or a variant of pituicytoma? A case report with review of literature. Neurol India. 2018 Sep-Oct; 66(5):1413-1418.

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Bauer P, Kreuz FR, B?rk K, Saft C, Andrich J, Heilemann H, Riess O, Sch?ls L. Mutations in TITF1 are not relevant to sporadic and familial chorea of unknown cause. Mov Disord. 2006 Oct; 21(10):1734-7.

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Doyle DA, Gonzalez I, Thomas B, Scavina M. Autosomal dominant transmission of congenital hypothyroidism, neonatal respiratory distress, and ataxia caused by a mutation of NKX2-1. J Pediatr. 2004 Aug; 145(2):190-3.

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Spilde TL, Bhatia AM, Miller KA, Ostlie DJ, Chaignaud BE, Holcomb GW, Snyder CL, Gittes GK. Thyroid transcription factor-1 expression in the human neonatal tracheoesophageal fistula. J Pediatr Surg. 2002 Jul; 37(7):1065-7.

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Miettinen M, Franssila KO. Variable expression of keratins and nearly uniform lack of thyroid transcription factor 1 in thyroid anaplastic carcinoma. Hum Pathol. 2000 Sep; 31(9):1139-45.

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Strayer DS, Korutla L. Activation of surfactant protein-B transcription: signaling through the SP-A receptor utilizing the PI3 kinase pathway. J Cell Physiol. 2000 Aug; 184(2):229-38.

View in: PubMed

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