NF-kappa B

"NF-kappa B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

Descriptor ID	D016328
MeSH Number(s)	D12.776.260.600 D12.776.660.600 D12.776.930.600
Concept/Terms	NF-kappa B NF-kappa B kappa B Enhancer Binding Protein NF-kappaB NF kappaB Transcription Factor NF-kB Factor NF-kB, Transcription NF-kB, Transcription Factor Transcription Factor NF kB NF-kB NF kB Immunoglobulin Enhancer-Binding Protein Enhancer-Binding Protein, Immunoglobulin Immunoglobulin Enhancer Binding Protein Nuclear Factor kappa B Ig-EBP-1 Ig-EBP-1 Ig EBP 1

Below are MeSH descriptors whose meaning is more general than "NF-kappa B".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
NF-kappa B [D12.776.260.600]
Nuclear Proteins [D12.776.660]
NF-kappa B [D12.776.660.600]
Transcription Factors [D12.776.930]
NF-kappa B [D12.776.930.600]

Below are MeSH descriptors whose meaning is related to "NF-kappa B".

Below are MeSH descriptors whose meaning is more specific than "NF-kappa B".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NF-kappa B" by people in this website by year, and whether "NF-kappa B" was a major or minor topic of these publications.

Bar chart showing 251 publications over 28 distinct years, with a maximum of 21 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	1	2
1998	1	0	1
1999	8	1	9
2000	6	1	7
2001	4	2	6
2002	7	11	18
2003	7	5	12
2004	6	5	11
2005	7	9	16
2006	10	8	18
2007	7	11	18
2008	5	5	10
2009	6	6	12
2010	7	5	12
2011	6	5	11
2012	1	8	9
2013	4	5	9
2014	2	13	15
2015	8	13	21
2016	3	5	8
2017	1	5	6
2018	0	2	2
2019	2	0	2
2020	0	5	5
2021	1	2	3
2022	3	0	3
2023	1	2	3
2024	1	1	2

Below are the most recent publications written about "NF-kappa B" by people in Profiles.

Guo ZF, Tongmuang N, Li C, Zhang C, Hu L, Capreri D, Zuo MX, Summer R, Sun J. Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice. JCI Insight. 2024 Sep 10; 9(17).

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Anilkumar S, Wright-Jin E. NF-?B as an Inducible Regulator of Inflammation in the Central Nervous System. Cells. 2024 03 11; 13(6).

View in: PubMed
Roche ME, Ko YH, Domingo-Vidal M, Lin Z, Whitaker-Menezes D, Birbe RC, Tuluc M, Gyorffy B, Caro J, Philp NJ, Bartrons R, Martinez-Outschoorn U. TP53 Induced Glycolysis and Apoptosis Regulator and Monocarboxylate Transporter 4 drive metabolic reprogramming with c-MYC and NFkB activation in breast cancer. Int J Cancer. 2023 11 01; 153(9):1671-1683.

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Jain S, Saha P, Syamprasad NP, Panda SR, Rajdev B, Jannu AK, Sharma P, Naidu VGM. Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-?B axis. Clin Sci (Lond). 2023 05 31; 137(10):785-805.

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Rocha SM, Kirkley KS, Chatterjee D, Aboellail TA, Smeyne RJ, Tjalkens RB. Microglia-specific knock-out of NF-?B/IKK2 increases the accumulation of misfolded a-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease. Glia. 2023 09; 71(9):2154-2179.

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Merline R, R?dig H, Zeng-Brouwers J, Poluzzi C, Tascher G, Michaelis J, Lopez-Mosqueda J, Rhiner A, Huber LS, Diehl V, Dikic I, K?gel D, M?nch C, Wygrecka M, Schaefer L. A20 binding and inhibitor of nuclear factor kappa B (NF-?B)-1 (ABIN-1): a novel modulator of mitochondrial autophagy. Am J Physiol Cell Physiol. 2023 02 01; 324(2):C339-C352.

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Wang V, Heffer A, Roztocil E, Feldon SE, Libby RT, Woeller CF, Kuriyan AE. TNF-a and NF-?B signaling play a critical role in cigarette smoke-induced epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy. PLoS One. 2022; 17(9):e0271950.

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Florio TJ, Lokareddy RK, Yeggoni DP, Sankhala RS, Ott CA, Gillilan RE, Cingolani G. Differential recognition of canonical NF-?B dimers by Importin a3. Nat Commun. 2022 03 08; 13(1):1207.

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Vazquez C, Swanson SE, Negatu SG, Dittmar M, Miller J, Ramage HR, Cherry S, Jurado KA. SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms. PLoS One. 2021; 16(6):e0253089.

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Hokello J, Sharma AL, Tyagi M. Combinatorial Use of Both Epigenetic and Non-Epigenetic Mechanisms to Efficiently Reactivate HIV Latency. Int J Mol Sci. 2021 Apr 02; 22(7).

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