Proto-Oncogene Proteins c-jun

"Proto-Oncogene Proteins c-jun" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.

Descriptor ID	D016755
MeSH Number(s)	D12.776.260.108.820 D12.776.624.664.700.182 D12.776.660.763 D12.776.930.127.820
Concept/Terms	Proto-Oncogene Proteins c-jun Proto-Oncogene Proteins c-jun Proto Oncogene Proteins c jun c-jun Proteins c jun Proteins fos-Associated Protein p39 fos Associated Protein p39 jun Proto-Oncogene Product p39 jun Proto Oncogene Product p39 jun Proto-Oncogene Proteins jun Proto Oncogene Proteins p39 c-jun p39 c jun p39(c-jun) Proto-Oncogene Products c-jun Proto Oncogene Products c jun c-fos-Associated Protein p39 c fos Associated Protein p39 Proto-Oncogene Proteins jun Proto Oncogene Proteins jun jun D Proteins jun D Proteins jun B Proteins jun B Proteins

Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-jun".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Basic-Leucine Zipper Transcription Factors [D12.776.260.108]
Proto-Oncogene Proteins c-jun [D12.776.260.108.820]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
Proto-Oncogene Proteins c-jun [D12.776.624.664.700.182]
Nuclear Proteins [D12.776.660]
Proto-Oncogene Proteins c-jun [D12.776.660.763]
Transcription Factors [D12.776.930]
Basic-Leucine Zipper Transcription Factors [D12.776.930.127]
Proto-Oncogene Proteins c-jun [D12.776.930.127.820]

Below are MeSH descriptors whose meaning is related to "Proto-Oncogene Proteins c-jun".

Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-jun".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proto-Oncogene Proteins c-jun" by people in this website by year, and whether "Proto-Oncogene Proteins c-jun" was a major or minor topic of these publications.

Bar chart showing 21 publications over 15 distinct years, with a maximum of 2 publications in 1995 and 2002 and 2003 and 2006 and 2007 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1992	1	0	1
1993	0	1	1
1994	1	0	1
1995	1	1	2
1997	0	1	1
1998	0	1	1
1999	0	1	1
2002	0	2	2
2003	1	1	2
2005	1	0	1
2006	2	0	2
2007	0	2	2
2008	0	1	1
2009	0	1	1
2010	2	0	2

Below are the most recent publications written about "Proto-Oncogene Proteins c-jun" by people in Profiles.

Katiyar S, Casimiro MC, Dettin L, Ju X, Wagner EF, Tanaka H, Pestell RG. C-jun inhibits mammary apoptosis in vivo. Mol Biol Cell. 2010 Dec; 21(23):4264-74.

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Jiao X, Katiyar S, Willmarth NE, Liu M, Ma X, Flomenberg N, Lisanti MP, Pestell RG. c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion. J Biol Chem. 2010 Mar 12; 285(11):8218-26.

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Ponticos M, Holmes AM, Shi-wen X, Leoni P, Khan K, Rajkumar VS, Hoyles RK, Bou-Gharios G, Black CM, Denton CP, Abraham DJ, Leask A, Lindahl GE. Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. Arthritis Rheum. 2009 Jul; 60(7):2142-55.

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Vasilevskaya IA, Selvakumaran M, O'Dwyer PJ. Disruption of signaling through SEK1 and MKK7 yields differential responses in hypoxic colon cancer cells treated with oxaliplatin. Mol Pharmacol. 2008 Jul; 74(1):246-54.

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Boyd JD, Jang H, Shepherd KR, Faherty C, Slack S, Jiao Y, Smeyne RJ. Response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) differs in mouse strains and reveals a divergence in JNK signaling and COX-2 induction prior to loss of neurons in the substantia nigra pars compacta. Brain Res. 2007 Oct 17; 1175:107-16.

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Fernando R, Foster JS, Bible A, Ström A, Pestell RG, Rao M, Saxton A, Baek SJ, Yamaguchi K, Donnell R, Cekanova M, Wimalasena J. Breast cancer cell proliferation is inhibited by BAD: regulation of cyclin D1. J Biol Chem. 2007 Sep 28; 282(39):28864-73.

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Wu K, Liu M, Li A, Donninger H, Rao M, Jiao X, Lisanti MP, Cvekl A, Birrer M, Pestell RG. Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth. Mol Biol Cell. 2007 Mar; 18(3):755-67.

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Katiyar S, Jiao X, Wagner E, Lisanti MP, Pestell RG. Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor. Mol Cell Biol. 2007 Feb; 27(4):1356-69.

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Bu X, Avraham HK, Li X, Lim B, Jiang S, Fu Y, Pestell RG, Avraham S. Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells. Oncogene. 2005 Mar 31; 24(14):2398-409.

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Vasilevskaya I, O'Dwyer PJ. Role of Jun and Jun kinase in resistance of cancer cells to therapy. Drug Resist Updat. 2003 Jun; 6(3):147-56.

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