Proto-Oncogene Proteins c-akt

"Proto-Oncogene Proteins c-akt" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.

Descriptor ID	D051057
MeSH Number(s)	D08.811.913.696.620.682.700.755 D12.776.476.565 D12.776.624.664.700.168
Concept/Terms	Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-akt Proto Oncogene Proteins c akt c-akt, Proto-Oncogene Proteins Protein Kinase B Proto-Oncogene Protein RAC Proto Oncogene Protein RAC RAC, Proto-Oncogene Protein Proto-Oncogene Protein Akt Akt, Proto-Oncogene Protein Proto Oncogene Protein Akt Rac Protein Kinase akt Proto-Oncogene Protein Protein, akt Proto-Oncogene Proto-Oncogene Protein, akt akt Proto Oncogene Protein RAC-PK Protein RAC PK Protein Related to A and C-Protein Related to A and C Protein c-akt Proto-Oncogene Protein Protein, c-akt Proto-Oncogene Proto-Oncogene Protein, c-akt c akt Proto Oncogene Protein c-akt Protein Protein-Serine-Threonine Kinase (Rac) Proto-Oncogene Proteins c-akt1 Proto-Oncogene Proteins c-akt1 Proteins c-akt1, Proto-Oncogene Proto Oncogene Proteins c akt1 c-akt1, Proto-Oncogene Proteins AKT1 Protein Kinase Rac-PK alpha Protein Rac PK alpha Protein alpha Protein, Rac-PK Protein Kinase B alpha Akt-alpha Protein Akt alpha Protein Proto-Oncogene Proteins c-akt2 Proto-Oncogene Proteins c-akt2 Proteins c-akt2, Proto-Oncogene Proto Oncogene Proteins c akt2 c-akt2, Proto-Oncogene Proteins Protein Kinase B beta Rac-PK beta Protein Rac PK beta Protein AKT2 Protein Kinase Akt-beta Protein Akt beta Protein Proto-Oncogene Proteins c-akt3 Proto-Oncogene Proteins c-akt3 Proteins c-akt3, Proto-Oncogene Proto Oncogene Proteins c akt3 c-akt3, Proto-Oncogene Proteins Akt-gamma Protein Akt gamma Protein AKT3 Protein Kinase Protein Kinase B gamma

Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-akt".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Proto-Oncogene Proteins c-akt [D08.811.913.696.620.682.700.755]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Proto-Oncogene Proteins c-akt [D12.776.476.565]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
Proto-Oncogene Proteins c-akt [D12.776.624.664.700.168]

Below are MeSH descriptors whose meaning is related to "Proto-Oncogene Proteins c-akt".

Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-akt".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proto-Oncogene Proteins c-akt" by people in this website by year, and whether "Proto-Oncogene Proteins c-akt" was a major or minor topic of these publications.

Bar chart showing 174 publications over 23 distinct years, with a maximum of 18 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	2	2
2001	0	1	1
2002	0	8	8
2003	0	7	7
2004	0	5	5
2005	4	10	14
2006	1	8	9
2007	5	11	16
2008	4	11	15
2009	8	10	18
2010	5	7	12
2011	5	9	14
2012	4	6	10
2013	0	4	4
2014	3	10	13
2015	1	5	6
2016	1	3	4
2017	1	1	2
2018	4	2	6
2019	0	2	2
2020	0	1	1
2022	0	3	3
2023	1	1	2

Below are the most recent publications written about "Proto-Oncogene Proteins c-akt" by people in Profiles.

Lumpkin CJ, Harris AW, Connell AJ, Kirk RW, Whiting JA, Saieva L, Pellizzoni L, Burghes AHM, Butchbach MER. Evaluation of the orally bioavailable 4-phenylbutyrate-tethered trichostatin A analogue AR42 in models of spinal muscular atrophy. Sci Rep. 2023 06 26; 13(1):10374.

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L? J, Zhao Q, Guo Y, Li D, Xie H, Liu C, Hu X, Liu S, Hou Z, Wei X, Zheng D, Pestell RG, Yu Z. Regulation of ERa-dependent breast cancer metastasis by a miR-29a signaling. J Exp Clin Cancer Res. 2023 Apr 20; 42(1):93.

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Manai M, ELBini-Dhouib I, Finetti P, Bichiou H, Reduzzi C, Aissaoui D, Ben-Hamida N, Agavnian E, Srairi-Abid N, Lopez M, Amri F, Guizani-Tabbane L, Rahal K, Mrad K, Manai M, Birnbaum D, Mamessier E, Cristofanilli M, Boussen H, Kharrat M, Doghri R, Bertucci F. MARCKS as a Potential Therapeutic Target in Inflammatory Breast Cancer. Cells. 2022 09 19; 11(18).

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Menko AS, Walker JL. The Pro-Fibrotic Response to Lens Injury Is Signaled in a PI3K Isoform-Specific Manner. Biomolecules. 2022 08 25; 12(9).

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Kao CY, Jiang J, Thompson W, Papoutsakis ET. miR-486-5p and miR-22-3p Enable Megakaryocytic Differentiation of Hematopoietic Stem and Progenitor Cells without Thrombopoietin. Int J Mol Sci. 2022 May 11; 23(10).

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Asadi-Pooya AA. Rediscovery of Rue for the treatment of epilepsy. Epilepsy Res. 2020 11; 167:106434.

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Meister KS, Godse NR, Khan NI, Hedberg ML, Kemp C, Kulkarni S, Alvarado D, LaVallee T, Kim S, Grandis JR, Duvvuri U. HER3 targeting potentiates growth suppressive effects of the PI3K inhibitor BYL719 in pre-clinical models of head and neck squamous cell carcinoma. Sci Rep. 2019 06 24; 9(1):9130.

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Barta SK, Zain J, MacFarlane AW, Smith SM, Ruan J, Fung HC, Tan CR, Yang Y, Alpaugh RK, Dulaimi E, Ross EA, Campbell KS, Khan N, Siddharta R, Fowler NH, Fisher RI, Oki Y. Phase II Study of the PD-1 Inhibitor Pembrolizumab for the Treatment of Relapsed or Refractory Mature T-cell Lymphoma. Clin Lymphoma Myeloma Leuk. 2019 06; 19(6):356-364.e3.

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Xie Y, Shi X, Sheng K, Han G, Li W, Zhao Q, Jiang B, Feng J, Li J, Gu Y. PI3K/Akt signaling transduction pathway, erythropoiesis and glycolysis in hypoxia (Review). Mol Med Rep. 2019 Feb; 19(2):783-791.

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Szymonowicz K, Oeck S, Krysztofiak A, van der Linden J, Iliakis G, Jendrossek V. Restraining Akt1 Phosphorylation Attenuates the Repair of Radiation-Induced DNA Double-Strand Breaks and Reduces the Survival of Irradiated Cancer Cells. Int J Mol Sci. 2018 Jul 31; 19(8).

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