Proto-Oncogene Proteins c-akt

"Proto-Oncogene Proteins c-akt" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.

Descriptor ID	D051057
MeSH Number(s)	D08.811.913.696.620.682.700.755 D12.776.476.565 D12.776.624.664.700.168
Concept/Terms	Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-akt Proto Oncogene Proteins c akt c-akt, Proto-Oncogene Proteins Protein Kinase B Proto-Oncogene Protein RAC Proto Oncogene Protein RAC RAC, Proto-Oncogene Protein Proto-Oncogene Protein Akt Akt, Proto-Oncogene Protein Proto Oncogene Protein Akt Rac Protein Kinase akt Proto-Oncogene Protein Protein, akt Proto-Oncogene Proto-Oncogene Protein, akt akt Proto Oncogene Protein RAC-PK Protein RAC PK Protein Related to A and C-Protein Related to A and C Protein c-akt Proto-Oncogene Protein Protein, c-akt Proto-Oncogene Proto-Oncogene Protein, c-akt c akt Proto Oncogene Protein c-akt Protein Protein-Serine-Threonine Kinase (Rac) Proto-Oncogene Proteins c-akt1 Proto-Oncogene Proteins c-akt1 Proteins c-akt1, Proto-Oncogene Proto Oncogene Proteins c akt1 c-akt1, Proto-Oncogene Proteins AKT1 Protein Kinase Rac-PK alpha Protein Rac PK alpha Protein alpha Protein, Rac-PK Protein Kinase B alpha Akt-alpha Protein Akt alpha Protein Proto-Oncogene Proteins c-akt2 Proto-Oncogene Proteins c-akt2 Proteins c-akt2, Proto-Oncogene Proto Oncogene Proteins c akt2 c-akt2, Proto-Oncogene Proteins Protein Kinase B beta Rac-PK beta Protein Rac PK beta Protein AKT2 Protein Kinase Akt-beta Protein Akt beta Protein Proto-Oncogene Proteins c-akt3 Proto-Oncogene Proteins c-akt3 Proteins c-akt3, Proto-Oncogene Proto Oncogene Proteins c akt3 c-akt3, Proto-Oncogene Proteins Akt-gamma Protein Akt gamma Protein AKT3 Protein Kinase Protein Kinase B gamma

Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-akt".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Proto-Oncogene Proteins c-akt [D08.811.913.696.620.682.700.755]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Proto-Oncogene Proteins c-akt [D12.776.476.565]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
Proto-Oncogene Proteins c-akt [D12.776.624.664.700.168]

Below are MeSH descriptors whose meaning is related to "Proto-Oncogene Proteins c-akt".

Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-akt".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proto-Oncogene Proteins c-akt" by people in this website by year, and whether "Proto-Oncogene Proteins c-akt" was a major or minor topic of these publications.

Bar chart showing 128 publications over 21 distinct years, with a maximum of 18 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1999	0	1	1
2001	0	1	1
2002	0	8	8
2003	0	6	6
2004	0	3	3
2005	4	8	12
2006	1	8	9
2007	3	8	11
2008	2	9	11
2009	9	9	18
2010	5	6	11
2011	4	5	9
2012	2	5	7
2013	0	2	2
2014	1	7	8
2015	0	2	2
2016	0	2	2
2017	0	1	1
2018	1	1	2
2022	0	3	3

Below are the most recent publications written about "Proto-Oncogene Proteins c-akt" by people in Profiles.

Kao CY, Jiang J, Thompson W, Papoutsakis ET. miR-486-5p and miR-22-3p Enable Megakaryocytic Differentiation of Hematopoietic Stem and Progenitor Cells without Thrombopoietin. Int J Mol Sci. 2022 May 11; 23(10).

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Tsoyi K, Esposito AJ, Sun B, Bowen RG, Xiong K, Poli F, Cardenas R, Chu SG, Liang X, Ryter SW, Beeton C, Doyle TJ, Robertson MJ, Celada LJ, Romero F, El-Chemaly SY, Perrella MA, Ho IC, Rosas IO. Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts. Sci Rep. 2022 02 18; 12(1):2847.

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Gheyas R, Ortega-Alvarez R, Chauss D, Kantorow M, Menko AS. Suppression of PI3K signaling is linked to autophagy activation and the spatiotemporal induction of the lens organelle free zone. Exp Cell Res. 2022 03 15; 412(2):113043.

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Yan W, Wu K, Herman JG, Xu X, Yang Y, Dai G, Guo M. Retinoic acid-induced 2 (RAI2) is a novel tumor suppressor, and promoter region methylation of RAI2 is a poor prognostic marker in colorectal cancer. Clin Epigenetics. 2018; 10:69.

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Geyer FC, Li A, Papanastasiou AD, Smith A, Selenica P, Burke KA, Edelweiss M, Wen HC, Piscuoglio S, Schultheis AM, Martelotto LG, Pareja F, Kumar R, Brandes A, Fan D, Basili T, Da Cruz Paula A, Lozada JR, Blecua P, Muenst S, Jungbluth AA, Foschini MP, Wen HY, Brogi E, Palazzo J, Rubin BP, Ng CKY, Norton L, Varga Z, Ellis IO, Rakha EA, Chandarlapaty S, Weigelt B, Reis-Filho JS. Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas. Nat Commun. 2018 05 08; 9(1):1816.

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Costa R, Shah AN, Santa-Maria CA, Cruz MR, Mahalingam D, Carneiro BA, Chae YK, Cristofanilli M, Gradishar WJ, Giles FJ. Targeting Epidermal Growth Factor Receptor in triple negative breast cancer: New discoveries and practical insights for drug development. Cancer Treat Rev. 2017 Feb; 53:111-119.

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Klayman LM, Wedegaertner PB. Inducible Inhibition of Gß? Reveals Localization-dependent Functions at the Plasma Membrane and Golgi. J Biol Chem. 2017 Feb 03; 292(5):1773-1784.

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Neill T, Buraschi S, Goyal A, Sharpe C, Natkanski E, Schaefer L, Morrione A, Iozzo RV. EphA2 is a functional receptor for the growth factor progranulin. J Cell Biol. 2016 Dec 05; 215(5):687-703.

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Winters B, Plymate S, Zeliadt SB, Holt S, Zhang X, Hu E, Lin DW, Morrissey C, Wooldridge B, Gore JL, Porter MP, Wright JL. Metformin effects on biochemical recurrence and metabolic signaling in the prostate. Prostate. 2015 Nov; 75(15):1694-703.

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Jain A, Lai JC, Bhushan A. Biochanin A inhibits endothelial cell functions and proangiogenic pathways: implications in glioma therapy. Anticancer Drugs. 2015 Mar; 26(3):323-30.

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